Results 131 to 140 of about 166,612,573 (299)

Analysis of antibiotic use in vap (ventilator-association pneumonia) patients [PDF]

, 2013
VAP is a nosocomial infection that most often occurs in the ICU. VAP increases morbidity, mortality, treatment costs andhospitalization time in the ICU. Antibiotic is primary therapy in VAP.
Agung Dwi Wahyu Widodo, Budi Suprapti, Maharani Wahyuning Tyas, Hardiono   +3 more
core   +1 more source

Impact of a Multifaceted Antimicrobial Stewardship Program on Antimicrobial Use and Prescription Quality in a Pediatric Intensive Care Unit: An Interrupted Time-Series Study

Antibiotics
Background: Inappropriate antibiotic use contributes to antimicrobial resistance. Evidence regarding the impact of antimicrobial stewardship programs (ASPs) in pediatric intensive care units (PICUs) remains limited.
Laura Fernández-Vallespin, Elena Fresán-Ruiz, Maria Goretti López-Ramos, Ángela Pieras-López, Eneritz Velasco-Arnaiz, Iolanda Jordan   +5 more
doaj   +1 more source

O06 Development of AWaRe antibiotic quality indicators for optimal use

JAC-Antimicrobial Resistance
Abstract Background The use of antibiotics varies by setting—hospital, outpatient/primary care—with a disproportionate impact of antimicrobial resistance in low-and middle-income countries.
Heath, Annie, Goelen, Jan, Chuki, Pem, Cook, Aislinn, Djukic, Filip, Thuy Do, Nga Thi, Funiciello, Elisa, Gaundra, Sumanth, Godman, Brian, Khalaf, Yara Mohsen, Lorenzetti, Guilia, Mendelson, Marc, Moore, Catrin E, Osorio-de-Castro, Claudia G S, Saleem, Zikria, Schouten, Jeroen, Tayler, Elizabeth, Wesangula, Evelyn, Delphi Panel, A W aR e-B ased Q I s, Campbell, Stephen M, Sharland, Michael   +20 more
openaire   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Small area variations and welfare loss in the use of antibiotics in the community [PDF]

This paper seeks to explain local variations in the use of antibiotics in the community and to assess the welfare loss due to heterogeneous attitudes towards the risk of bacterial infections and resistance. Significant differences are observed in the per
Karine Moschetti, Massimo Filippini, Giuliano Masiero   +2 more
core  

Minimum Antibiotic Levels for Selecting a Resistance Plasmid in a Gnotobiotic Animal Model [PDF]

, 1989
The minimum antibiotic concentrations for selecting an R plasmid in vivo were determined in germfree rates colonized by two isogenic strains of Escherichia coli, one of which carried an R plasmid.
Lumeau, Solange, Corpet, Denis E., Corpet, Florence   +2 more
core  

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

AN EQUILIBRIUM ANALYSIS OF ANTIBIOTICS USE AND REPLANTING DECISIONS IN APPLE PRODUCTION [PDF]

Antibiotics are used in fruit production to control fire blight, a bacterial disease of fruit trees that causes yield losses and eventually tree death.
Hennessy, David A., Roosen, Jutta
core  

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

The Relationship Between Appropriateness of Antibiotic Use Based on the Gyssens Algorithm and Mortality: A Retrospective Cohort Study in Indonesian Tertiary Hospital

Acta Medica Indonesiana
Background: Some studies have reported that antibiotic use as therapy and prophylaxis in hospitals is inappropriate in approximately 9% to 64% of cases. The Gyssens algorithm is used for qualitative evaluation by assessing the appropriate antibiotic use.
Fadrian Fadrian, Gestina Aliska, Widya Nur Utami   +2 more
doaj   +2 more sources