Results 131 to 140 of about 5,811,138 (314)

A Scoping Review on Quality Physical Education Programmes and Their Outcomes on Primary-Level Pupils. [PDF]

open access: yesInt J Environ Res Public Health, 2023
Kingston Ú   +3 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Measuring Instruction in Higher Education: Summary of a Convening [PDF]

open access: yes, 2015
What will it take to improve the quality of instruction in higher education? An important first step is the ability to measure quality. A variety of measurement systems exist, but how informative are they, and how can we bring greater coherence to ...

core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Comparison of residents’ approaches to clinical decisions before and after the implementation of Evidence Based Medicine course

open access: yesJournal of Advances in Medical Education and Professionalism, 2014
Introduction: It has been found that the decision-making process in medicine is affected, to a large extent, by one’s experience, individual mentality, previous models, and common habitual approaches, in addition to scientific principles.
ZAHRA KARIMIAN   +6 more
doaj  

First Class in Learning -- First Class in Life: How Washington's Early Childhood Education Career and Wage Ladder Delivers First-Class Care [PDF]

open access: yes, 2010
High-quality early learning cannot be achieved or sustained when the bonds between teacher and child are broken because teachers leave their jobs to gain higher paid employment in order to support their own families.
Gary Burris, Hannah Lidman, John Burbank
core  

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