Results 161 to 170 of about 178,634,582 (237)

Use of Hospital Information System to Improve the Quality of Health Care from Clinical Staff Perspective. [PDF]

Galen Med J, 2021
Mohammadpour A, Ghaemi MM, Darrudi R, Sadagheyani HE.   +3 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Health professionals' competence for the provision of quality primary health care in Amhara region, Ethiopia. [PDF]

PLoS One
Tsega G, Woldie M, Yismaw G, Degu G.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Facilitators and barriers to health professionals' competence in delivering quality primary health care in the digital era in Amhara region, Ethiopia: an exploratory qualitative study. [PDF]

BMC Prim Care
Tsega G, Woldie M, Yismaw G, Degu G.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Racial and Ethnic Disparities in Accessing High-Quality Home Health Care among Older Adults with and Without Dementia. [PDF]

J Am Med Dir Assoc
Ma C, Wu B, Brody AA.
europepmc   +1 more source

Low back pain and its correlations with poor sleep quality among health care providers. [PDF]

J Taibah Univ Med Sci, 2022
AlHamam NM, Buhalim RA, AlSaeed MN, AlFuraikh BF, AlJughaiman MS.   +4 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Why patient safety is akin to weaving textiles: an International Society for Quality in Health Care perspective on the 7th Global Ministerial Summit on Patient Safety 2025. [PDF]

Int J Qual Health Care
Braithwaite J, Pichumani A, Ushiro S, Thompson L, Hibbert P, Garcia Elorrio E.   +5 more
europepmc   +1 more source