Results 181 to 190 of about 2,166,352 (310)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Barriers and facilitators to quality mental health care for forcibly displaced children and adolescents in the WHO European Region: protocol for a scoping review. [PDF]

BMJ Open
Dumke L, Nagraj S, Abukmail H, Behrendt M, Cinar EN, Giannaki A, Hall J, Razai MS, Schäfer I, Whyatt G, Chatburn E.   +10 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Detecting and preventing financial abuse of older adults: Examining decision making by health, social care and banking professionals

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Financial elder abuse is gaining increasing attention from researchers and policy makers.
Davies, Miranda Louise
core  

Risk formulation, lived experience, and patient leadership in European CAMHS

Public Health Reviews
Nadia Ahmed, Sophie Mae Harrington, Aikaterina Sidiroglou, Paul Louis Fiedler, Hannah Brunskill, Jennifer Hall, Ledia Lazeri, Joao Breda   +7 more
doaj   +1 more source

Health professionals' competence for the provision of quality primary health care in Amhara region, Ethiopia. [PDF]

PLoS One
Tsega G, Woldie M, Yismaw G, Degu G.
europepmc   +1 more source

Use of Hospital Information System to Improve the Quality of Health Care from Clinical Staff Perspective. [PDF]

Galen Med J, 2021
Mohammadpour A, Ghaemi MM, Darrudi R, Sadagheyani HE.   +3 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Improving the quality of health care when health workers are in short supply [PDF]

A number of low- and middle-income countries have a severe shortage of health workers. This paper studies how health workers’ choices of labour supply and work effort impact on the quality of health services when health workers are in short supply.
Torsvik, Gaute, Mæstad, Ottar
core  

Facilitators and barriers to health professionals' competence in delivering quality primary health care in the digital era in Amhara region, Ethiopia: an exploratory qualitative study. [PDF]

BMC Prim Care
Tsega G, Woldie M, Yismaw G, Degu G.
europepmc   +1 more source