Results 201 to 210 of about 4,872,997 (355)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Satisfaction With Quality of Health Care Among Medicare Beneficiaries With Functional Hearing Loss. [PDF]

Med Care, 2021
Reed NS, Boss EF, Lin FR, Oh ES, Willink A.   +4 more
europepmc   +1 more source

Quality of health care with regard to detection and treatment of mental disorders in patients with coronary heart disease (MenDis-CHD): study protocol [PDF]

, 2019
Samia Peltzer, Hendrik Müller, Ursula Köstler, Katja Blaschke, Frank Schulz‐Nieswandt, Frank Jessen, Christian Albus, Christian Albus   +7 more
openalex   +1 more source

Factors That Affect Opioid Quality Improvement Initiatives in Primary Care: Insights from Ten Health Systems

, 2022
Ellen Childs, Colette A. Tano, Christina A. Mikosz, Michael L. Parchman, Catherine L. Hersey, Nicole Keane, Sarah Shoemaker‐Hunt, Jan L. Losby   +7 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Facilitators and barriers to health professionals' competence in delivering quality primary health care in the digital era in Amhara region, Ethiopia: an exploratory qualitative study. [PDF]

BMC Prim Care
Tsega G, Woldie M, Yismaw G, Degu G.
europepmc   +1 more source

Low back pain and its correlations with poor sleep quality among health care providers. [PDF]

J Taibah Univ Med Sci, 2022
AlHamam NM, Buhalim RA, AlSaeed MN, AlFuraikh BF, AlJughaiman MS.   +4 more
europepmc   +1 more source

Supply Chain Management and Its Effect on Health Care Service Quality: Quantitative Evidence from Jordanian Private Hospitals

, 2013
Raeeda Jamal Al-Saa'da, Yara Khalid Abu Taleb, Mais Elian Al Abdallat, Rasmi Abd Alraheem Al-Mahasneh, Nabil Awni Nimer, Ghazi A. Al-Weshah   +5 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Health professionals' competence for the provision of quality primary health care in Amhara region, Ethiopia. [PDF]

PLoS One
Tsega G, Woldie M, Yismaw G, Degu G.
europepmc   +1 more source