Results 131 to 140 of about 169,134,263 (293)
Scientific ReportsThis exploratory study examined the effects of player number and pitch size on internal and external load during small-sided Ultimate Frisbee games (SSGs) in elite male athletes and explored associations between playing density, expressed as area per ...
Davide Morri +3 more
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Quality of life of Chinese cancer patients: optimism as mediator
, 2002 8th Annual Conference of the International Society for Quality of Life Research (ISOQOL), Amsterdam, The Netherlands, 7-10 November 2001. In Quality of Life Research, 2002, v. 10 n. 3, p.
Sham, JST +3 more
core
The development of a quality of life instrument for osteoarthritis [PDF]
, 2007 Osteoarthritis (OA) is a common condition and a leading cause of pain and disability. The aim of this thesis was to explore issues associated with living with OA, develop an OA specific quality of life instrument and explore the physical and psychosocial
Keenan, Anne-Maree
core
European Journal of Vascular and Endovascular Surgery, 1995 Perkins, J.M.T., O'Brien, T.S.
openaire +2 more sources
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Note de cercetare despre studiul comunităţilor rurale în România de astăzi
Sociologie Românească, 2010 Studying community is very common in current Romanian academic and non-academic research. For instance, assessing the impact of most development projects requires the study of the potentially affected communities, both before, during and after the ...
Bogdan Voicu +4 more
doaj
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source