Results 71 to 80 of about 169,134,263 (293)

General population normative values for the EORTC QLQ-C30 by age, sex, and health condition for the French general population

Journal of Patient-Reported Outcomes
Background General population normative values for the widely used health-related quality of life (HRQoL) measure EORTC QLQ-C30 support the interpretation of trial results and HRQoL of patients in clinical practice. Here, we provide sex-, age- and health
Micha J. Pilz, Fanny L.C. Loth, Sandra Nolte, Anna M.M. Thurner, Eva-Maria Gamper, Amélie Anota, Gregor Liegl, Johannes M. Giesinger, on behalf of the EORTC Quality of Life Group   +8 more
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The value and quality of life

European Review, 1999
A medical view on ‘the value of life’ can be inferred from medical accounts of the quality of life: a life has value if it embodies certain qualities. Scales have been developed to quantify quality of life. While the term ‘quality of life’ is used frequently in everyday discourse, perceptions of what it might actually mean differ greatly and are often ...
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

European Quality of Life Survey, 2011-2012

, 2013
copyright UK Data Service and data collection copyright owner.   Carried out every four years, the European Quality of Life Survey (EQLS) examines both the objective circumstances of European citizens' lives and how they feel about those ...
European Foundation for the Improvement of Living and Working Conditions
core   +4 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Trajectories of quality of life in patients with traumatic limb injury: a 2-year follow-up study

, 2017
Purpose Traumatic limb injury (TLI) can have a negative impact on a patient's quality of life (QOL), and the patient's QOL may fluctuate over time. However, the longitudinal change patterns of QOL in patients with TLI are largely unknown. The aim of this
Lin, Gong-Hong; Huang, Yi-Jing; Huang, Chien-Yu; Lu, Wen-Shian; Chen, Sheng-Shiung; Hou, Wen-Hsuan; Hsieh, Ching-Lin
core   +1 more source

C-QUALITY: cost and quality-of-life pharmacoeconomic analysis of antidepressants used in major depressive disorder in the regional Italian settings of Veneto and Sardinia

ClinicoEconomics and Outcomes Research, 2013
Claudio Mencacci,1 Eugenio Aguglia,2 Giovanni Biggio,3 Lodovico Cappellari,4 Guido Di Sciascio,5 Andrea Fagiolini,6 Giuseppe Maina,7 Alfonso Tortorella,8 Pablo Katz,9 Claudio Ripellino9 1Department of Mental Health, Fatebenefratelli Hospital, Milan ...
Mencacci C, Aguglia E, Biggio G, Cappellari L, Di Sciascio G, Fagiolini A, Maina G, Tortorella A, Katz P, Ripellino C   +9 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source