Results 81 to 90 of about 169,134,263 (293)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Determinants of quality of life in community-dwelling older adults: comparing three cut-offs on the excellent-to-poor spectrum.

, 2017
The aim of this study was to identify modifications in health, economic and social determinants of quality of life (QoL) in community-dwelling older adults when using different cut-offs to defining favorable QoL.
Santos-Eggimann, B., Büla, C., Cornaz, S., Botrugno, F., Henchoz, Y., Charef, S.   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Womens Perceptions of Their Husbands Drinking Behavior as a Risk Factor of Their Health-Related Quality of Life in the Postpartum Period

, 2012
The objective of this study is to investigate the association between womens perceptions of their husbands drinking behavior and their health- related quality of life HRQOL in the postpartum period.
CHANG, PEI-JEN;WU, LI-YAO;CHEN, YI-CHUN;CHUANG, CHAO-HUA;HSIEH, WU-SHIUN;LIN, SHIO-JEAN;CHEN, PAU-CHUNG, 張蓓貞;吳禮堯;陳意淳;莊昭華;謝武勳;林秀娟;陳保中   +1 more
core   +1 more source

Quality of life in end of life

GeroScience
Assessing quality of life (QOL) in end-of-life patients is vital for understanding the complex impacts of terminal illnesses on individual well-being. This study aims to compare two widely used QOL assessment tools: the Karnofsky Performance Status Scale (KPSS) and the Short-Form-36 (SF-36) Health Survey among patients with late-stage diseases. KPSS, a
Valeriani, Lavinia, Carrano, Barbara, Vecchio, Fabrizio   +2 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Quimp (quality of life impairment): an addition to the quality of life lexicon

Journal of the European Academy of Dermatology and Venereology, 2017
There has been a constant growth in the number of publications each year concerning “quality of life (QoL)” and “dermatology,” since the publication of the Dermatology Life Quality Index in 1994. Numerous dermatology and disease-specific QoL instruments have since been created.
Chernyshov, Pavel P.V., Bewley, Anthony, van Cranenburgh, Oda O.D., Jemec, Gregor, Salek, Sam S.S., Sampogna, Francesca, Svensson, Linder, Michael Dennis, Pustišek, Nives, Manolache, Liana, Szepietowski, Jacek J.C., Tomas-Aragones, Lucía, Marron, Servando S.E., Poot, Françoise, Augustin, Matthias   +14 more
openaire   +5 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A Rasch Analysis of a Self-Perceived Change in Quality of Life Scale in Patients with Mild Stroke

, 2009
A Rasch analysis was used to assess the unidimensionality and appropriateness of the scoring level of a 13-item self- perceived change in quality of life scale (CQOL) for stroke patients.
林昭宏;王文中;許清芳;盧成皆;薛漪平;謝清麟, LIN, JAU-HONG;WANG, WEN-CHUNG;SHEU, CHING-FAN;LO, SING-KAI;HUSEH, I-PING;HSIEH, CHING-LIN   +1 more
core  

Quality of Life in Adult Individuals Living With or at Risk of a Hereditary Cancer Predisposition Syndrome: A Scoping Review of the Qualitative Literature

Cancer Medicine
Background The in‐depth understanding of the impact of a hereditary cancer predisposition syndrome (HCPS) on the health‐related quality of life (HRQOL) of individuals with a hereditary cancer burden contributes to the improvement of counselling ...
M. Sztankay, S. Wheelwright, V. Vassiliou, E. M. A. Bleiker, B. Rahman, B. Holzner, A. Yener, V. Engele, A. S. Oberguggenberger, EORTC Quality of Life Group   +9 more
doaj   +1 more source