Results 81 to 90 of about 2,742,255 (313)

The anti-IgE antibody omalizumab improves asthma-related quality of life in patients with allergic asthma [PDF]

, 2002
Roland Buhl, G. Hanf, M. Solèr, George Bensch, Jeremy D. Wolfe, F Everhard, Kate Champain, H. Fox, J. Thirlwell   +8 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Persistent Effect of Red Cell Transfusion on Health-Related Quality of Life After Cardiac Surgery [PDF]

, 2006
Colleen G. Koch, Farah Khandwala, Liang Li, Fawzy G. Estafanous, Floyd D. Loop, Eugene H. Blackstone   +5 more
openalex   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

International child health. Measuring health-related quality of life in a child population [PDF]

, 1999
Erik Verrips
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Glaucoma Quality of Life [PDF]

Journal of Ophthalmology, 2017
FEA, Antonio Maria, Hengerer, Fritz, LAVIA, Carlo Alessandro, Au, Leon   +3 more
openaire   +5 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A qualitative study to understand public views on the relative value of health gains for children and young people in Australia compared to adults.

PLoS ONE
ObjectivesStandard economic evaluation methods assume that quality-adjusted life years (QALYs) have equal social value, regardless of recipient. However, evidence suggests that people place greater social value on health gains for children.
Ashwini De Silva, Cate Bailey, Nancy Devlin, Richard Norman, Tianxin Pan, Tessa Peasgood, QUality Of life in Kids: Key evidence to strengthen decisions in Australia (QUOKKA) project team   +6 more
doaj   +1 more source