Results 81 to 90 of about 166,477,360 (253)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Department of Administrative Services (DAS) program on resident bidders under Public Act 11-229

, 2012
"Pursuant to the provisions of section 9 of Public Act 11-229, the Department of Administrative Services (DAS) in consultation with the Commissioner of Labor, the President of the University of Connecticut, the Commissioner of Public Works (now the ...
Connecticut. Dept. of Administrative Services.
core  

Reimagining patient-reported outcomes in the age of generative AI

npj Digital Medicine
Generative artificial intelligence, particularly large language models, offers an opportunity to rethink how patient-reported outcomes (PROs) are assessed and implemented in health systems.
Laurent Boyer, Sara Fernandes, Pascal Auquier, Bruno Falissard, Trishan Panch   +4 more
doaj   +1 more source

Análise estratégica sobre o emprego de federação de identidade no canal de Internet das organizações Identity federation on organizational internet channel strategic analysis

Production, 2007
A Federação de Identidade, como um padrão de segurança e de intermediação de informações privadas de identidade, desponta como uma solução real no mercado e tem tomado corpo através de três alianças ou grupos: Shibboleth, WS-Federation e Liberty Alliance.
Heitor Luiz Murat de Meirelles Quintella, José Marcelo de Freitas Vilela   +1 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Annual report/ Connecticut Department of Revenue Services. FY 2001-2002

, 2002
Annual; Description based on: 1982/1983.; Latest issue consulted: 2006/2007.; Fiscal years 2003/2004 and 2004/2005 combined.; Report year ends June 30.; Prepared by the Dept.
Connecticut. Dept. of Revenue Services.
core   +1 more source

Preference-oriented quality of life monitoring and linkage with clinical registry data: study protocol of a randomised clinical trial in patients with lung cancer (LePaLuMo Study)

Trials
Background In routine oncological care, the implementation of disease-related quality of life (QoL) is still an open matter. In a complex intervention, a QoL monitoring system including tailored therapeutic options has been designed, implemented, and its
Patricia Lindberg-Scharf, Martin Emmert, Michael Koller, Florian Gürtler, Brunhilde Steinger, Jacqueline Müller-Nordhorn, Florian Zeman, Sophie Friebel, Ksenia Ibler, Jan Kurz, Thomas Stangl, Monika Klinkhammer-Schalke, Vinzenz Völkel   +12 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source