Results 41 to 50 of about 1,788,201 (258)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Work on Quality of Work Life

International Journal of Recent Technology and Engineering, 2019
The present period is a time of learning laborers and the general public where in we are living has come, to be known as information society. The scholarly interests have outweighed the physical endeavors. Some information laborers work for over 60 hours every week. Subsequently, their own diversions and interests conflict with their work.
openaire   +1 more source

Assessment of quality of life, job insecurity and work ability among nurses, working either under temporary or permanent terms

International Journal of Occupational Medicine and Environmental Health
Objectives Aim of this study was to assess and compare health, quality of life, well-being, job satisfaction and job insecurity between nurses, in a tertiary hospital in Greece, working either under permanent or temporary contract.
Maria Katsaouni, Gregory Tripsianis, Theodoros Constantinidis, Konstantinos Vadikolias, Christos Kontogiorgis, Aspasia Serdari, Aikaterini Arvaniti, Evangelos Theodorou, Evangelia Nena   +8 more
doaj   +1 more source

Quality Of Work Life dan Komitmen Organisasi Terhadap Peningkatan Motivasi Kerja PNS: Studi Kausal Pada Pegawai Kantor Kecamatan Cakung Kota Administratif Jakarta Timur

Jurnal Manajemen, 2018
This study was conducted to determine whether the Quality of Work Life and Organizational Commitment significant impact either partially or simultaneously to Work Motivation employee District Office Cakung East Jakarta Administration City. The population
Dian Riskarini
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Quality of Work Life: Employee Performance Nexus and the Moderating Effect of Employee Commitment

International Journal of Multidisciplinary Educational Research and Innovation
This study determines how employee commitment influenced the relationship between quality of work life and employee performance. A non-experimental quantitative research design with a descriptive correlational and regression approach was employed on 900 ...
Romel C. Nemiño
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Comparison of Relationship between Quality of Public Life and Quality Dedicated to Working Life in the Presence of the Mediator role of Work Conflict: A Multi-Group Analysis

علوم بهداشتی ایران, 2018
Background and purpose: The concepts of work and life have the strongest and most effective relationship with individuals and society, and making a balance between them can have a direct impact on the achievement of organizational goals.
Mohtaram Zabihi, Ghahraman Mahmoudi, Ghassem Abedi   +2 more
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source