Results 101 to 110 of about 2,852,414 (315)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Exposure to chemicals and metals and risk of amyotrophic lateral sclerosis: a systematic review

, 2009
Environmental exposure to chemicals and metals may contribute to the risk of sporadic amyotrophic lateral sclerosis (ALS). Two systematic reviews of the literature on these topics performed according to the well-established MOOSE guidelines are presented.
Veldink, J.H., van den Berg, L.H., Dep IRAS, Huisman, M.H.B., Heederik, D.J.J., Risk Assessment of Toxic and Immunomodulatory Agents, Wokke, J.H.J., Sutedja, N.A., Fischer, K., Kromhout, H.   +9 more
core   +1 more source

Effectiveness of Biochar on Cd Migration and Bioaccumulation in a Multi-Species Alkaline Fluvo-Aquic Soil System

Agronomy
Cadmium (Cd) contamination in alkaline soils threatens wheat safety in northern China. This study evaluates biochar’s dual role in Cd remediation and ecological trade-offs using a multi-species soil system (wheat–earthworm–soil).
Dongqin Li, Changhong Lai, Hongzhi He, Dian Wen, Yiran Cao, Zhichao Wu, Furong Li, Hanzhi Shi, Xu Wang, Guikui Chen   +9 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Rapid Synthesis: Identifying Risk and Protective Factors for Quality Clinical Practice [PDF]

, 2015
An assessment of what is known about identifying risk and protective factors for quality clinical practice. The rapid synthesis was conducted to address a question posed by a health system policymaker or stakeholder to the McMaster Health Forum’s Rapid ...
Randhawa, H, Wilson, MG, Lavis, JN
core  

Health-risk behaviors and quality of life among young men.

, 2014
PURPOSE: To examine the associations between substance use and other health-risk behaviors and quality of life (QOL) among young men. METHODS: The analytical sample consisted of 5,306 young Swiss men who participated in the Cohort Study on Substance Use ...
Gmel, G., Dey, M., Studer, J., Mohler-Kuo, M.   +3 more
core   +1 more source

The Potential Role of Camel Milk in Alleviating Chronic Fatigue Syndrome in Mice: A Network Pharmacology and In Vivo Validation Study

Foods
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a complex and debilitating disorder with limited treatment options. Camel milk (CM), known for its rich nutrients and anti-fatigue properties, may offer multi-target benefits for managing ...
Hongman Li, Henigul Osman, Hongyan Zhang, He Chen, Nan Zheng, Yankun Zhao, Shiqi Zhang   +6 more
doaj   +1 more source

Statistical Modeling for Quality Risk Assessment of Clinical Trials: Follow-Up at the Era of Remote Auditing. [PDF]

Ther Innov Regul Sci, 2022
Koneswarakantha B, Ménard T.
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Quality Risk and Profitability in Cattle Production: A Multivariate Approach

This study evaluates quality, production, and price risk within the context of overall profit variability in fed cattle production. The approach used offers a flexible way to estimate a large system of equations with more than three jointly related ...
Goodwin, Barry K., Schroeder, Ted C., Belasco, Eric J.   +2 more
core