Results 81 to 90 of about 2,852,414 (315)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Conducting Ecological Risk Assessments at Remediation Sites in Texas [PDF]

, 2017
This publication outlines the TCEQ's ecological risk assessment program and describes the interface between the ERA program and the Texas Risk Reduction Program(TRRP ...
Texas Commission on Environmental Quality, Remediation Division   +1 more
core  

Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity

Advanced Science
α−Sulfide disulfides represent valuable motifs in organic and pharmaceutical chemistry. However, the limited availability of synthetic approaches for α−sulfide disulfides has impeded progress in this field.
Qingqiang Tian, Chuxia Wang, Bingrui Liu, Xiangwei Wu, Yahui Li   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Impact assessment of differential chlormequat chloride exposure on soil fungal community dynamics

Frontiers in Microbiology
IntroductionThis study investigated the dose-dependent effects of chlormequat chloride (CC) applications on soil fungal community structure and diversity in a peanut cultivation system.MethodsA controlled field experiment was conducted with four ...
Qiujun Lin, Qiujun Lin, Xianxin Wu, Xianxin Wu, Lina Li, Lina Li, Tianshu Peng, Tianshu Peng, Xun Zou, Xun Zou, Guang Li, Guang Li, Jianzhong Wang, Jianzhong Wang, Chunjing Guo, Chunjing Guo   +15 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Comparative analysis of nutritional composition and medicinal potential between two halophytic species Suaeda salsa and Suaeda heteroptera

Industrial Crops and Products
Background: Suaeda salsa and Suaeda heteroptera co-occur on saline–alkali lands in Dongying (Shandong, China) and were promising food resources, yet systematic comparisons of their nutritional and functional properties were limited. Objective: To compare
Jingxiu Bi, Xiangjun Ma, Pingxiang Liu, Rui Gao, Tong Zhao, Xuexia Yuan, Haining Hao, Yutao Wang   +7 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source