Results 101 to 110 of about 12,856,576 (256)
PharmaceuticsBackground/Objectives: Quality by Design (QbD) has revolutionized pharmaceutical development by transitioning from reactive quality testing to proactive, science-driven methodologies.
Shiwei Yang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Product Quality in Different Markets and Cost Structure [PDF]
This paper analyzes the behavior of monopoly firm serving its products to two countries. The main focus of this paper is on how the product-quality choice in different markets are related with the cost structure of the firm.
Kiyoshi Matsubara
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Target Validation:Linking Target and Chemical Properties to Desired Product Profile
, 2011 The discovery of drugs is a lengthy, high-risk and expensive business taking at least 12 years and is estimated to cost upwards of US$800 million for each drug to be successfully approved for clinical use.
Read, Kevin D. +7 more
core +2 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Product Quality in the Food Chain: Do Cooperatives Offer High Quality Products? [PDF]
Cooperatives and investor-owned firms are alternative forms of business organisation that coexist and compete in many markets. The theoretical literature has identified a number of comparative advantages and disadvantages of cooperatives.
Weiss, Christoph R. +1 more
core
THE IMPACT OF THE LUBRICATION STEP WITH MAGNESIUM STEARATE ON THE QUALITY TARGET PRODUCT PROFILE OF A MODIFIED RELEASE ORAL DOSAGE FORM CONTAINING A BCS CLASS II ACTIVE PHARMACEUTICAL INGREDIENT [PDF]
FARMACIA, 2020 openaire +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Estimating Cross-Country Differences in Product Quality [PDF]
We develop a method for decomposing countries' observed export prices into quality versus quality-adjusted-price components using information contained in their trade balances.
Peter K. Schott, Juan Carlos Hallak
core