Results 41 to 50 of about 928,612 (281)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Journal of Sensor and Actuator Networks, 2012 The number of devices on the Internet exceeded the number of people on the Internet in 2008, and is estimated to reach 50 billion in 2020. A wide-ranging Internet of Things (IOT) ecosystem is emerging to support the process of connecting real-world ...
Melanie Swan
doaj +1 more source
Phonon Josephson Junction with Nanomechanical Resonators [PDF]
, 2016 We study coherent phonon oscillations and tunneling between two coupled nonlinear nanomechanical resonators. We show that the coupling between two nanomechanical resonators creates an effective phonon Josephson junction which exhibits two different ...
Barzanjeh, Shabir, Vitali, David
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Information Quality Challenges of Patient-Generated Data in Clinical Practice
Frontiers in Public Health, 2017 A characteristic trend of digital health has been the dramatic increase in patient-generated data being presented to clinicians, which follows from the increased ubiquity of self-tracking practices by individuals, driven, in turn, by the proliferation of
Peter West +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
NEAT-Lamp and Talking Tree: Beyond Personal Informatics towards Active Workplaces
Computers, 2017 A growing number of personal informatics (PI) systems have been designed to break the habit of prolonged sitting and to encourage physical activity during workdays and leisure hours.
Fatemeh Moradi, Mikael Wiberg
doaj +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source
L’usage des objets connectés dans le cyclisme : étude sur les tendances et les pratiques émergentes
Revue Française des Sciences de l’Information et de la Communication, 2018 The world of sport, whether professional or amateur, is becoming one of the privileged fields of use for connected objects which are now present in all activities (running, football, cycling, tennis…).
Feirouz Boudokhane-Lima
doaj +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source