Results 121 to 130 of about 8,273,226 (310)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
e-Assessment: past, present and future
, 2014 The goal of this paper is to provide an overview of the evolution of electronic assessment, or e-assessment, within the context of a developing e-pedagogy by investigating the changes occurring over time in the ways e-pedagogy is described.
Hench, Thomas
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Assessment item generation, the way forward
, 2014 Automatic item generation (AIG) supports in particular computerised adaptive testing, although it is now used in other contexts, in particular to extract items from learning texts or domain models.
Foulonneau, Muriel, Ras, Eric
core
Advancing the Contribution of Occupational Epidemiology to Risk Assessment [PDF]
, 2011 The identification and quantification of risk factors that are characterized by low exposure levels, moderately increased risks, and unspecific exposure-disease relations is a major challenge facing risk assessment today.
Vlaanderen, J.J. +2 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
e-Assessment tales: what types of literature are informing day-to-day practice?
, 2013 This desktop research commissioned by the Higher Education Academy set out to consult with the academic community about which references on assessment and feedback with technology- enhancement were most useful to practitioners. While all the recommended
Whitelock, Denise +2 more
core
, 1973 This report covers in detail all of the various and varying areas and concepts contained in the "Environmental Assessment Outline: Wayne Township". It includes: a description of the proposed project; background information on the geography, natural ...
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source