Results 71 to 80 of about 789,997 (243)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Strengths and Weaknesses of the Current Strategies to Map and Characterize R-Loops

Non-Coding RNA, 2018
R-loops are evolutionarily conserved three-stranded structures that result from the formation of stable DNA:RNA hybrids in the genome. R-loops have attracted increasing interest in recent years as potent regulators of gene expression and genome stability.
Vincent Vanoosthuyse
doaj   +1 more source

Analysis of monotonicity properties of some rule interestingness measures [PDF]

, 2009
One of the crucial problems in the field of knowledge discovery is development of good interestingness measures for evaluation of the discovered patterns.
Greco, Salvatore, Slowinski, R., Szczech, I.   +2 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Formal Fuzzy Concept-Based Approach for Association Rule Discovery with Optimized Time and Storage

Mathematics
Association Rule Mining (ARM) relies on concept lattices as an effective knowledge representation structure. However, classical ARM methods face significant limitations, including the generation of misleading rules during data-to-formal-context mapping ...
Gamal F. Elhady, Haitham Elwahsh, Maazen Alsabaan, Mohamed I. Ibrahem, Ebtesam Shemis   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A Fuzzy Approach to Weighted Temporal Mining Using Automatic Weight Assignment with Reduced Complexities

Journal of Algorithms & Computational Technology, 2010
Databases and data warehouses have become a vital part of many organizations. So useful information and helpful knowledge have to be mined from transactions.
C. Balasubramanian, K. Duraiswamy, V. Palanisamy   +2 more
doaj   +1 more source

Utilization of Data Mining Techniques in SIMPUS towards Smart Library at IAIN Kendari [PDF]

E3S Web of Conferences
The use of data mining techniques in the Library Management Information System (SIMPUS) has great potential to support the transformation of conventional libraries into Smart Libraries. This study aims to analyze the application of data mining techniques
Samrin, Badarwan, Raehang, Obaid Moh. Yahya, Syahrul   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

QCBA: Postoptimization of Quantitative Attributes in Classifiers based on Association Rules

, 2019
The need to prediscretize numeric attributes before they can be used in association rule learning is a source of inefficiencies in the resulting classifier.
Kliegr, Tomas
core