Results 31 to 40 of about 12,268 (219)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Non-abstractness as mental simulation in the representation of number

, 2009
ion is instrumental for our understanding of how numbers are cognitively represented. We propose that the notion of abstraction becomes testable from within the framework of simulated cognition.
Myachykov, Andriy, Fischer, M.H., Myachykov, A., Platenburg, W.P.A., Fischer, Martin H., Platenburg, Wouter P. A., Platenburg, Wouter, Fischer, Martin   +7 more
core   +1 more source

A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons

, 2020
Full author list omitted for brevity. For the full list of authors, see article.BACKGROUND: Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain's neuronal population and mediate cognition, food intake, and metabolism.
Akbarian, Schahram, Espeso-Gil, Sergio, Borrman, Tyler M., Weng, Zhiping   +3 more
core   +1 more source

Different brain circuits underlie motor and perceptual representations of temporal intervals [PDF]

, 2008
In everyday life, temporal information is used for both perception and action, but whether these two functions reflect the operation of similar or different neural circuits is unclear.
Walsh, V., Bueti, D., Rees, G., Chris Frith, Frith, C, Bueti, Domenica, Walsh, V, Vincent Walsh, Geraint Rees, Frith, C., Domenica Bueti   +10 more
core   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Toward a computational framework for cognitive biology: Unifying approaches from cognitive neuroscience and comparative cognition

, 2014
Progress in understanding cognition requires a quantitative, theoretical framework, grounded in the other natural sciences and able to bridge between implementational, algorithmic and computational levels of explanation.
Fitch, W. Tecumseh, W. Tecumseh Fitch
core   +1 more source

Topology and Material Optimization in Ultra‐Soft Magneto‐Active Structures: Making Advantage of Residual Anisotropies

Advanced Materials, EarlyView.
Residual magnetization induces pronounced mechanical anisotropy in ultra‐soft magnetorheological elastomers, shaping deformation and actuation even without external magnetic fields. This study introduces a computational‐experimental framework integrating magneto‐mechanical coupling into topology optimization for designing soft magnetic actuators with ...
Carlos Perez‐Garcia, Rogelio Ortigosa, Jesús Martínez‐Frutos, Daniel Garcia‐Gonzalez   +3 more
wiley   +1 more source

Disentangling the Roles of Approach, Activation and Valence in Instrumental and Pavlovian Responding

, 2011
Hard-wired, Pavlovian, responses elicited by predictions of rewards and punishments exert significant benevolent and malevolent influences over instrumentally-appropriate actions.
Dayan, P., Dayan, P, Quentin J. M. Huys, Golzer, M, Dolan, R., Heinz, A, Huys, Q., Huys, QJM, Friedel, E, Golzer, M., Huys, Q.J.M., Eva Friedel, Raymond J. Dolan, Andreas Heinz, Cools Roshan, Heinz Andreas, Dolan, RJ, Cools, R, Dolan Raymond J., Dayan Peter, Cools, R., Quentin J M Huys, Dolan, R. ; https://orcid.org/, Raymond J Dolan, Peter Dayan, Dolan, R.J., Roshan Cools, Huys Quentin J. M., Friedel, E., Gölzer Martin, Martin Gölzer, Heinz, A., Friedel Eva   +32 more
core   +1 more source

Cross-species differences in color categorization [PDF]

, 2006
International audienceBerlin and Kay (1969) found systematic restrictions in the color terms of the world's languages and were inclined to look to the primate visual system for their origin.
Davidoff, Jules B., Fagot, J., Davidoff, Jules, Goldstein, J., Julie Goldstein, Alan Pickering, Goldstein, Julie, Joël Fagot, Jules Davidoff, Fagot, Joël, Pickering, Alan   +10 more
core   +1 more source

Double‐Transition‐Metal MXenes: Multimetallic 2D Platforms for Next‐Generation Biomedicine

Advanced Materials, EarlyView.
The present work explores recent progress in double‐transition‐metal MXenes and focuses on their potential as multifunctional biomedical nanoplatforms whose tunable optical, electronic, mechanical, and surface properties enable imaging, theranostics, antimicrobial activity, biosensing, tissue engineering, and drug delivery.
Parsa Namakiaraghi, Mohammad Mozafari, Masoud Soroush   +2 more
wiley   +1 more source