Results 31 to 40 of about 2,262,296 (287)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Toll Based Measures for Dynamical Graphs [PDF]

, 2007
Biological networks are one of the most studied object in computational biology. Several methods have been developed for studying qualitative properties of biological networks.
Bourdon, Jérémie, Eveillard, Damien
core   +2 more sources

Detection of regulator genes and eQTLs in gene networks

, 2016
Genetic differences between individuals associated to quantitative phenotypic traits, including disease states, are usually found in non-coding genomic regions.
A Butte, A Chatr-Aryamontri, A Clauset, A Joshi, A Joshi, A Kundaje, AA Shabalin, AJ Enright, AJ Walhout, AS Dimas, B Schwanhausser, B Zhang, B Zhang, C Cenik, CO Daub, D Koller, DA Cusanovich, DM Greenawalt, E Bonnet, E Ravasz, E Segal, EC Neto, EC Neto, EC Neto, EE Schadt, EE Schadt, EE Schadt, EE Schadt, EE Schadt, EJ Foss, F Grubert, F Yue, FA Cubillos, FW Albert, G Hemani, G Nicholson, GD Smith, GH Golub, H Foroughi Asl, H Talukdar, HN Kadarmideen, J Millstein, J Qi, J Zhu, J Zhu, J Zhu, JE Aten, JF Ayroles, JJ Faith, JL Björkegren, JS Liu, K Basso, K Qu, KG Ardlie, L Wu, LA Hindorff, LH Hartwell, LS Chen, M Ashburner, M Civelek, M Georges, M Gerstein, M Medvedovic, M Schmidt, M Scutari, MA Schaub, MB Eisen, MD Ritchie, ME Goddard, MEJ Newman, MEJ Newman, MV Rockman, MV Rockman, N Friedman, N Friedman, N Friedman, N Laird, O Stegle, P Langfelder, P Langfelder, P Langfelder, P Lu, R Sharan, R Sharan, RB Brem, RW Williams, S Lee, S Roy, S Tavazoie, SI Lee, SM Waszak, SS Rao, T Lappalainen, T Michoel, TA Manolio, TF Mackay, The ENCODE, TS Furey, VG Cheung, W Cookson, W Zhang, Y Chen, Y Li   +102 more
core   +1 more source

Interactions between nutrition and gastrointestinal infections with parasitic nematodes in goats [PDF]

, 2005
Parasitic nematodes of the digestive tract remain one of the main constraints to goat production both in temperate and tropical countries. The usual mode of control of these gastrointestinal nematodes (GIN) based on the repeated use of anthelmintics is
A., Aguilar-Caballero, C., Broqua, C., Chartier, E., Etter, H., Hoste, J.F., Torres-Acosta, V., Paolini, Y., Lefrileux   +7 more
core   +1 more source

Molecular Biology at the Quantum Level: Can Modern Density Functional Theory Forge the Path? [PDF]

Nano LIFE, 2(2):1230006, 2012, 2012
Recent years have seen vast improvements in the ability of rigorous quantum-mechanical methods to treat systems of interest to molecular biology. In this review article, we survey common computational methods used to study such large, weakly bound systems, starting from classical simulations and reaching to quantum chemistry and density functional ...
arxiv   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Modelling human embryoid body cell adhesion to a combinatorial library of polymer surfaces [PDF]

, 2012
Designing materials to control biology is an intense focus of biomaterials and regenerative medicine research. Discovering and designing materials with appropriate biological compatibility or active control of cells and tissues is being increasingly ...
Anderson, Andrew L. Hook, Burden, Burden, Burden, Curtis, Daniel G. Anderson, David A. Winkler, Gasteiger, Hook, Hook, Jing Yang, Le, Martyn C. Davies, Mauri, Mei, Mei, Menzies, Morgan R. Alexander, Robert Langer, Robinson, Szott, Taylor, Taylor, Unadkat, Urquhart, Urquhart, V. Chandana Epa, Wilson, Winkler, Yang, Ying Mei   +31 more
core   +3 more sources

Comment on "Comparative evaluation of two dose optimization methods for image-guided, highly-conformal, tandem and ovoids cervix brachytherapy planning" [PDF]

Physics in Medicine and Biology, 60(2), 537, 2013, 2015
Comparison of optimization algorithms for inverse treatment planning requires objective function value evaluation.
arxiv   +1 more source

Image processing and analysis methods in quantitative endothelial cell biology

, 2016
W. S. N. Grimes
openalex   +2 more sources

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source