Results 91 to 100 of about 3,681,793 (314)

Mississippi Semester: New Social Justice Approach to Teaching Empirical Reasoning in Context

open access: yesNumeracy, 2019
Under the direction of Professor Premilla Nadasen at Barnard College, the course “Mississippi Semester,” brings together a small group of undergraduate students in a collaborative action-driven project with Mississippi Low-Income Child-Care Initiative ...
Premilla Nadasen   +3 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Book Review: Great help for novice GT researchers

open access: yesGrounded Theory Review: An International Journal, 2016
The authors’ main purpose of the book is to provide practical guidance for novice researchers using classic grounded theory (GT) while remaining as true as possible to Glaser’s and Strauss’ thoughts.
Tove Giske
doaj  

How do emigrants perceive changes in their L1: influence of sociolinguistic factors

open access: yesTaikomoji kalbotyra, 2017
The paper aims at providing insights into sociolinguistic factors which affect the understanding of the first-generation emigrants that their L1 is different (or not) from Lithuanian used in Lithuania. The data for the analysis comes from the project The
Loreta Vilkienė
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Replication data for: Topological Feature Engineering for Machine Learning Based Halide Perovskite Materials Design

open access: yes, 2022
Accelerated materials development with machine learning (ML) assisted screening and high throughput experimentation for new photovoltaic materials holds the key to addressing our grand energy challenges.
Xu, Qiang   +4 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

From the Editor

open access: yesGrounded Theory Review: An International Journal, 2007
This issue of the Review combines a strong focus on classic grounded theory methodology with our continued practice of featuring the work of novice grounded theorists.
Judith A. Holton
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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