Results 91 to 100 of about 7,544,658 (347)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Mississippi Semester: New Social Justice Approach to Teaching Empirical Reasoning in Context

open access: yesNumeracy, 2019
Under the direction of Professor Premilla Nadasen at Barnard College, the course “Mississippi Semester,” brings together a small group of undergraduate students in a collaborative action-driven project with Mississippi Low-Income Child-Care Initiative ...
Premilla Nadasen   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Book Review: Great help for novice GT researchers

open access: yesGrounded Theory Review: An International Journal, 2016
The authors’ main purpose of the book is to provide practical guidance for novice researchers using classic grounded theory (GT) while remaining as true as possible to Glaser’s and Strauss’ thoughts.
Tove Giske
doaj  

Studying Flow Close to an Interface by Total Internal Reflection Fluorescence Cross Correlation Spectroscopy: Quantitative Data Analysis

open access: yes, 2011
Total Internal Reflection Fluorescence Cross Correlation Spectroscopy (TIR-FCCS) has recently (S. Yordanov et al., Optics Express 17, 21149 (2009)) been established as an experimental method to probe hydrodynamic flows near surfaces, on length scales of ...
B. Dünweg   +17 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

How do emigrants perceive changes in their L1: influence of sociolinguistic factors

open access: yesTaikomoji kalbotyra, 2017
The paper aims at providing insights into sociolinguistic factors which affect the understanding of the first-generation emigrants that their L1 is different (or not) from Lithuanian used in Lithuania. The data for the analysis comes from the project The
Loreta Vilkienė
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

From the Editor

open access: yesGrounded Theory Review: An International Journal, 2007
This issue of the Review combines a strong focus on classic grounded theory methodology with our continued practice of featuring the work of novice grounded theorists.
Judith A. Holton
doaj  

Updated, expanded, fluid properties handbook [PDF]

open access: yes, 1971
Revised handbook presents quantitative data, in the form of graphs and charts, pertaining to thermodynamic properties of specific cryogenic fluids and several metals.
Gershman, R.   +2 more
core   +1 more source

Home - About - Disclaimer - Privacy