Results 121 to 130 of about 3,681,793 (314)

Scholarly Communications & Data Management Tip Sheet: Finding Quantitative Datasets

, 2022
A dataset is a collection of data. Quantitative datasets contain data that can be quantified, or measured. Usually a quantitative dataset refers to the contents of a data table, in which each column represents a variable, and each row an item in the ...
Albertsons Library Research Data Management Group, Dworak, Ellie   +1 more
core  

Integrating Sustainability Pillars Into Trial Design Decision‐Making: Results of an International Survey

Clinical and Translational Science
The pharmaceutical industry is increasingly shifting to decentralized clinical trials (DCTs) conducted at the patient's home, sometimes including trial material home delivery.
Pritibha Singh, Oleksandr Sverdlov, Robert A. Beckman, Andrea M. Burden   +3 more
doaj   +1 more source

Empowering Educators and Students to Flourish: Evaluating the Student Alliance for Flourishing Program in Middle and High Schools

Education Sciences
There is a critical need to address the impact of the COVID-19 pandemic on the well-being of students and educators. In this article, we present findings from the second year of implementing the Student Alliance for Flourishing program, a school-wide ...
Kristine E. Larson, Molly S. Dunn, Beth-Ann Tek, Aubrie Lawler Justice   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Usage of big data for global tobacco control: exploring the trends in quantitative research from 2006 to 2015

, 2018
Background Measuring the impact of tobacco control initiatives like in other major themes of research relies on the data. Recently, there has been growing interest in the usability of big data which is characterized by large volumes, high computer ...
Hector Mongi
core   +1 more source

Multi-omics quantitative data of tomato fruit unveils regulation modes of least variable metabolites. [PDF]

BMC Plant Biol, 2023
Moing A, Berton T, Roch L, Diarrassouba S, Bernillon S, Arrivault S, Deborde C, Maucourt M, Cabasson C, Bénard C, Prigent S, Jacob D, Gibon Y, Lemaire-Chamley M.   +13 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Quantitative data collection approaches in subject-reported oral health research: a scoping review. [PDF]

BMC Oral Health, 2022
Maida CA, Xiong D, Marcus M, Zhou L, Huang Y, Lyu Y, Shen J, Osuna-Garcia A, Liu H.   +8 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source