Results 121 to 130 of about 7,544,658 (347)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Integrating Sustainability Pillars Into Trial Design Decision‐Making: Results of an International Survey

Clinical and Translational Science
The pharmaceutical industry is increasingly shifting to decentralized clinical trials (DCTs) conducted at the patient's home, sometimes including trial material home delivery.
Pritibha Singh, Oleksandr Sverdlov, Robert A. Beckman, Andrea M. Burden   +3 more
doaj   +1 more source

Empowering Educators and Students to Flourish: Evaluating the Student Alliance for Flourishing Program in Middle and High Schools

Education Sciences
There is a critical need to address the impact of the COVID-19 pandemic on the well-being of students and educators. In this article, we present findings from the second year of implementing the Student Alliance for Flourishing program, a school-wide ...
Kristine E. Larson, Molly S. Dunn, Beth-Ann Tek, Aubrie Lawler Justice   +3 more
doaj   +1 more source

Quantitative data collection approaches in subject-reported oral health research: a scoping review. [PDF]

BMC Oral Health, 2022
Maida CA, Xiong D, Marcus M, Zhou L, Huang Y, Lyu Y, Shen J, Osuna-Garcia A, Liu H.   +8 more
europepmc   +1 more source

Data from The Expression Quantitative Trait Loci in Immune Pathways and their Effect on Cutaneous Melanoma Prognosis

, 2023
Matjaž Vogelsang, Carlos Martínez, Justin Rendleman, Anuj Bapodra, Karolina Malecek, Artur Romanchuk, Esther Kazlow, Richard L. Shapiro, Russell S. Berman, Michelle Krogsgaard, Iman Osman, Tomas Kirchhoff   +11 more
openalex   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Quantitative Data Integration Analysis Method for Cross-Studies: Obstructive Sleep Apnea as an Example. [PDF]

Comput Math Methods Med, 2022
Zhou R, Zhou S, Xia Q, Zhang T, Zhang G.
europepmc   +1 more source

An improved comprehensive strategy for deep and quantitative N-glycomics based on optimization of sample preparation, isotope-based data quality control and quantification, new N-glycan libraries and new algorithms [PDF]

, 2020
Yudong Guan, Jiaxiang Hu, Weiqian Cao, Wencong Cui, Fan Yang, Christoph Krisp, Ling Lin, Min Zhang, Hannah Voß, Raphael Schuster, Guoquan Yan, Marceline Manka Fuh, Morten Thaysen‐Andersen, Nicolle H. Packer, Huali Shen, Pengyuan Yang, Hartmut Schlüter   +16 more
openalex   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Factors Contributing to Rationed Nursing Care in the Slovak Republic-A Secondary Analysis of Quantitative Data. [PDF]

Int J Environ Res Public Health, 2022
Kalánková D, Bartoníčková D, Kolarczyk E, Žiaková K, Młynarska A.   +4 more
europepmc   +1 more source