Results 81 to 90 of about 602,860 (218)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

METHOD DEVELOPMENT AND VALIDATION OF PHOTOMETRIC DETERMINATION OF IRON IN HEMOSTATIC TOOL

Разработка и регистрация лекарственных средств, 2019
The article presents data on the development of a technique of photometric determination of ferric chloride (III) as a hemostatic tool, through the formation of salicylates iron. The developed method was validated for following validation characteristics:
Yu. N. Barsukova, O. A. Melnikova, M. Yu. Melnikov   +2 more
doaj  

Proanthocyanidins from Camellia kwangsiensis with Potent Antioxidant and α-Glucosidase Inhibitory Activity

Foods
This study aimed to systematically investigate the chemical constituents and bioactivities of the traditional wild tea plant Camellia kwangsiensis Chang. An HPLC method was first established to simultaneously quantify five major components. Subsequently,
Na Li, Qin Ni, Min Chen, Hong-Tao Zhu, Man Zhang, Takashi Tanaka, Ying-Jun Zhang   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC TECHNIQUES OF DETERMINATION OF AMINOCAPROIC ACID IN A MULTI-COMPONENT HEMOSTATIC AGENT

Разработка и регистрация лекарственных средств, 2019
The article describes a method for quantitative determination of aminocaproic acid in a multi-component hemostatic medical agent having the local effect. The analysis uses the method of direct spectrophotometry with the wavelength of 568 nm. Based on the
Yu. N. Barsukova, O. A. Melnikova, M. Yu. Melnikov   +2 more
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

OPTIMIZATION OF HPLC METHODS FOR QUANTITATIVE DETERMINATION OF GLYCYRRHIZIC ACID IN LICORICE ROOTS

Разработка и регистрация лекарственных средств, 2019
Comparative evaluation of glycyrrhizic acid content in licorice roots by methods of UV-spectrophotometry (GF RF XIII) and high-performance liquid chromatography (HPLC) was carried out.
B. V. Brovchenko, V. A. Ermakova, A. N. Kuzmenko, I. A. Samylina, I. I. Krasnyuk (Jr.)   +4 more
doaj  

Standardisation of the method of residual organic solvent determination (review)

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. An important quality attribute of medicines and excipients is the content of residual organic solvents (ROS). The general chapter on ROS (1.1.0008) of the State Pharmacopoeia of the Russian Federation (Ph.
O. G. Kornilova, E. A. Smiryagin, V. L. Bagirova, M. A. Sumtsov   +3 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

High-performance liquid chromatography-tandem mass spectrometry for determination of milk fat globule membrane proteins in raw milk powder

Shipin yu jixie
ObjectiveTo establish a method for the quantitative detection of milk fat globule membrane proteins in raw milk powder based on characteristic peptides using liquid chromatography-tandem mass spectrometry.MethodsCharacteristic peptides are selected from ...
LIU Jianping, WANG Meiling, CHENG Jing, WANG Lin, ZHANG Fan, LI Guangsheng, LIU Yang, FANG Jing, LIU Xiangrong   +8 more
doaj   +1 more source