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Molecular and quantitative genetic variation within and between populations of the declining grassland species Saxifraga granulata [PDF]

Ecology and Evolution, 2022
Formerly common plant species are expected to be particularly susceptible to recent habitat fragmentation. We studied the population genetics of 19 recently fragmented Saxifraga granulata populations (max.
Tania J. Walisch, Guy Colling, Sylvie Hermant, Diethart Matthies   +3 more
doaj   +2 more sources

Flor Yeasts Rewire the Central Carbon Metabolism During Wine Alcoholic Fermentation

Frontiers in Fungal Biology, 2021
The identification of natural allelic variations controlling quantitative traits could contribute to decipher metabolic adaptation mechanisms within different populations of the same species.
Emilien Peltier, Emilien Peltier, Emilien Peltier, Charlotte Vion, Charlotte Vion, Omar Abou Saada, Anne Friedrich, Joseph Schacherer, Philippe Marullo, Philippe Marullo   +9 more
doaj   +1 more source

The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR‐Cas9 screen

FEBS Open Bio, 2022
Certain cancers, such as ovarian clear cell carcinoma (OCCC), display high levels of genetic variation between patients, making it difficult to develop effective therapies.
Brandon Cona, Tomoatsu Hayashi, Ai Yamada, Naomi Shimizu, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, Tetsu Akiyama   +7 more
doaj   +1 more source

CRISPR/Cas9 Screening for Identification of Genes Required for the Growth of Ovarian Clear Cell Carcinoma Cells

Current Issues in Molecular Biology, 2022
Epithelial ovarian cancer is classified into four major histological subtypes: serous, clear cell, endometrioid and mucinous. Ovarian clear cell carcinoma (OCCC) responds poorly to conventional chemotherapies and shows poor prognosis.
Ayako Kawabata, Tomoatsu Hayashi, Yoko Akasu-Nagayoshi, Ai Yamada, Naomi Shimizu, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, Aikou Okamoto, Tetsu Akiyama   +9 more
doaj   +1 more source

Invited review: Good practices in genome-wide association studies to identify candidate sequence variants in dairy cattle

Journal of Dairy Science, 2023
: Genotype data from dairy cattle selection programs have greatly facilitated GWAS to identify variants related to economic traits. Results can enhance the accuracy of genomic prediction, analyze more complex models that go beyond additive effects ...
G. Sahana, Z. Cai, M.P. Sanchez, A.C. Bouwman, D. Boichard   +4 more
doaj   +1 more source

Efficient Genome-wide Association in Biobanks Using Topic Modeling Identifies Multiple Novel Disease Loci

Molecular Medicine, 2017
Biobanks and national registries represent a powerful tool for genomic discovery, but rely on diagnostic codes that can be unreliable and fail to capture relationships between related diagnoses.
Thomas H. McCoy, Victor M. Castro, Leslie A. Snapper, Kamber L. Hart, Roy H. Perlis   +4 more
doaj   +1 more source

Genetic parameters of meat quality traits in two pig breeds measured by rapid methods

Animal, 2010
To study genetic variation in meat quality traits measured by rapid methods, data were recorded between 2005 and 2008 on samples of M. longissimus dorsi (LD) in Landrace (n = 3838) and Duroc (n = 2250) pigs included in the Norwegian pig breeding scheme ...
E. Gjerlaug-Enger, L. Aass, J. Ødegård, O. Vangen   +3 more
doaj   +1 more source

Weighted single-step genomic best linear unbiased prediction integrating variants selected from sequencing data by association and bioinformatics analyses

Genetics Selection Evolution, 2020
Background Sequencing data enable the detection of causal loci or single nucleotide polymorphisms (SNPs) highly linked to causal loci to improve genomic prediction.
Aoxing Liu, Mogens Sandø Lund, Didier Boichard, Emre Karaman, Bernt Guldbrandtsen, Sebastien Fritz, Gert Pedersen Aamand, Ulrik Sander Nielsen, Goutam Sahana, Yachun Wang, Guosheng Su   +10 more
doaj   +1 more source

The Opportunities and Challenges of Integrating Population Histories Into Genetic Studies for Diverse Populations: A Motivating Example From Native Hawaiians

Frontiers in Genetics, 2021
There is a well-recognized need to include diverse populations in genetic studies, but several obstacles continue to be prohibitive, including (but are not limited to) the difficulty of recruiting individuals from diverse populations in large numbers and
Charleston W. K. Chiang, Charleston W. K. Chiang   +1 more
doaj   +1 more source

Genomic selection on breeding time in a wild bird population

Evolution Letters, 2019
Artificial selection experiments are a powerful tool in evolutionary biology. Selecting individuals based on multimarker genotypes (genomic selection) has several advantages over phenotype‐based selection but has, so far, seen very limited use outside ...
Phillip Gienapp, Mario P. L. Calus, Veronika N. Laine, Marcel E. Visser   +3 more
doaj   +1 more source