Results 1 to 10 of about 7,425,705 (296)

A Quantitative Genetic Interaction Map of HIV Infection [PDF]

Mol Cell, 2020
We have developed a platform for quantitative genetic interaction mapping using viral infectivity as a functional read-out, and constructed a viral host-dependency epistasis map (vE-MAP) of 356 human genes linked to HIV function, comprising >63,000 pair ...
D. Gordon, Ariane Watson, Assen Roguev, Simin Zheng, Gwendolyn M. Jang, Joshua R Kane, Jiewei Xu, Jeffrey Z. Guo, Erica Stevenson, D. Swaney, K. Franks-Skiba, E. Verschueren, M. Shales, David C. Crosby, A. Frankel, A. Marson, Ivan Marazzi, G. Cagney, N. Krogan   +18 more
semanticscholar   +2 more sources

General Methods for Evolutionary Quantitative Genetic Inference from Generalized Mixed Models

Genetics, 2016
Methods for inference and interpretation of evolutionary quantitative genetic parameters, and for prediction of the response to selection, are best developed for traits with normal distributions.
Michael Morrissey, Shinichi Nakagawa, Pierre De Villemereuil   +2 more
exaly   +2 more sources

Molecular and quantitative genetic variation within and between populations of the declining grassland species Saxifraga granulata [PDF]

Ecology and Evolution, 2022
Formerly common plant species are expected to be particularly susceptible to recent habitat fragmentation. We studied the population genetics of 19 recently fragmented Saxifraga granulata populations (max.
Tania J. Walisch, Guy Colling, Sylvie Hermant, Diethart Matthies   +3 more
doaj   +2 more sources

The Genetic Architecture of Quantitative Traits Cannot Be Inferred from Variance Component Analysis

PLoS Genetics, 2016
Classical quantitative genetic analyses estimate additive and non-additive genetic and environmental components of variance from phenotypes of related individuals.
Wen Huang, Trudy Mackay
exaly   +2 more sources

Genetic mapping of quantitative trait loci in crops

Crop Journal, 2017
Dissecting the genetic architecture of complex traits is an ongoing challenge for geneticists. Two complementary approaches for genetic mapping, linkage mapping and association mapping have led to successful dissection of complex traits in many crop ...
Yang Xu, Pengcheng Li, Zefeng Yang, Chenwu Xu   +3 more
doaj   +2 more sources

Flor Yeasts Rewire the Central Carbon Metabolism During Wine Alcoholic Fermentation

Frontiers in Fungal Biology, 2021
The identification of natural allelic variations controlling quantitative traits could contribute to decipher metabolic adaptation mechanisms within different populations of the same species.
Emilien Peltier, Emilien Peltier, Emilien Peltier, Charlotte Vion, Charlotte Vion, Omar Abou Saada, Anne Friedrich, Joseph Schacherer, Philippe Marullo, Philippe Marullo   +9 more
doaj   +1 more source

The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR‐Cas9 screen

FEBS Open Bio, 2022
Certain cancers, such as ovarian clear cell carcinoma (OCCC), display high levels of genetic variation between patients, making it difficult to develop effective therapies.
Brandon Cona, Tomoatsu Hayashi, Ai Yamada, Naomi Shimizu, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, Tetsu Akiyama   +7 more
doaj   +1 more source

CRISPR/Cas9 Screening for Identification of Genes Required for the Growth of Ovarian Clear Cell Carcinoma Cells

Current Issues in Molecular Biology, 2022
Epithelial ovarian cancer is classified into four major histological subtypes: serous, clear cell, endometrioid and mucinous. Ovarian clear cell carcinoma (OCCC) responds poorly to conventional chemotherapies and shows poor prognosis.
Ayako Kawabata, Tomoatsu Hayashi, Yoko Akasu-Nagayoshi, Ai Yamada, Naomi Shimizu, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, Aikou Okamoto, Tetsu Akiyama   +9 more
doaj   +1 more source

Invited review: Good practices in genome-wide association studies to identify candidate sequence variants in dairy cattle

Journal of Dairy Science, 2023
: Genotype data from dairy cattle selection programs have greatly facilitated GWAS to identify variants related to economic traits. Results can enhance the accuracy of genomic prediction, analyze more complex models that go beyond additive effects ...
G. Sahana, Z. Cai, M.P. Sanchez, A.C. Bouwman, D. Boichard   +4 more
doaj   +1 more source

COMPARISON OF QUANTITATIVE GENETIC PARAMETERS [PDF]

Evolution, 1992
Shaw (1991) has described a maximum-likelihood procedure for comparing genetic covariance matrices between populations. While her efforts to expand the procedures available for quantitative genetic analyses are laudable, her discussion is incomplete in several respects. For example, consider her criticism of Dietz's matrix permutation test (Dietz, 1983)
David E, Cowley, William R, Atchley
openaire   +2 more sources