Results 1 to 10 of about 1,801,339 (187)

Molecular and quantitative genetic variation within and between populations of the declining grassland species Saxifraga granulata [PDF]

Ecology and Evolution, 2022
Formerly common plant species are expected to be particularly susceptible to recent habitat fragmentation. We studied the population genetics of 19 recently fragmented Saxifraga granulata populations (max.
Tania J. Walisch, Guy Colling, Sylvie Hermant, Diethart Matthies   +3 more
doaj   +2 more sources

Flor Yeasts Rewire the Central Carbon Metabolism During Wine Alcoholic Fermentation

Frontiers in Fungal Biology, 2021
The identification of natural allelic variations controlling quantitative traits could contribute to decipher metabolic adaptation mechanisms within different populations of the same species.
Emilien Peltier, Emilien Peltier, Emilien Peltier, Charlotte Vion, Charlotte Vion, Omar Abou Saada, Anne Friedrich, Joseph Schacherer, Philippe Marullo, Philippe Marullo   +9 more
doaj   +1 more source

The splicing factor DHX38/PRP16 is required for ovarian clear cell carcinoma tumorigenesis, as revealed by a CRISPR‐Cas9 screen

FEBS Open Bio, 2022
Certain cancers, such as ovarian clear cell carcinoma (OCCC), display high levels of genetic variation between patients, making it difficult to develop effective therapies.
Brandon Cona, Tomoatsu Hayashi, Ai Yamada, Naomi Shimizu, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, Tetsu Akiyama   +7 more
doaj   +1 more source

CRISPR/Cas9 Screening for Identification of Genes Required for the Growth of Ovarian Clear Cell Carcinoma Cells

Current Issues in Molecular Biology, 2022
Epithelial ovarian cancer is classified into four major histological subtypes: serous, clear cell, endometrioid and mucinous. Ovarian clear cell carcinoma (OCCC) responds poorly to conventional chemotherapies and shows poor prognosis.
Ayako Kawabata, Tomoatsu Hayashi, Yoko Akasu-Nagayoshi, Ai Yamada, Naomi Shimizu, Naoko Yokota, Ryuichiro Nakato, Katsuhiko Shirahige, Aikou Okamoto, Tetsu Akiyama   +9 more
doaj   +1 more source

Invited review: Good practices in genome-wide association studies to identify candidate sequence variants in dairy cattle

Journal of Dairy Science, 2023
: Genotype data from dairy cattle selection programs have greatly facilitated GWAS to identify variants related to economic traits. Results can enhance the accuracy of genomic prediction, analyze more complex models that go beyond additive effects ...
G. Sahana, Z. Cai, M.P. Sanchez, A.C. Bouwman, D. Boichard   +4 more
doaj   +1 more source

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change. [PDF]

, 2020
In pharmacogenomic studies of quantitative change, any association between genetic variants and the pretreatment (baseline) measurement can bias the estimate of effect between those variants and drug response.
Haldar, Tanushree, Hoffmann, Thomas J, Iribarren, Carlos, Krauss, Ronald M, Medina, Marisa W, Oni-Orisan, Akinyemi, Ranatunga, Dilrini K, Risch, Neil, Schaefer, Catherine   +8 more
core   +2 more sources

COMPARISON OF QUANTITATIVE GENETIC PARAMETERS [PDF]

Evolution, 1992
Shaw (1991) has described a maximum-likelihood procedure for comparing genetic covariance matrices between populations. While her efforts to expand the procedures available for quantitative genetic analyses are laudable, her discussion is incomplete in several respects. For example, consider her criticism of Dietz's matrix permutation test (Dietz, 1983)
David E, Cowley, William R, Atchley
openaire   +2 more sources

Efficient Genome-wide Association in Biobanks Using Topic Modeling Identifies Multiple Novel Disease Loci

Molecular Medicine, 2017
Biobanks and national registries represent a powerful tool for genomic discovery, but rely on diagnostic codes that can be unreliable and fail to capture relationships between related diagnoses.
Thomas H. McCoy, Victor M. Castro, Leslie A. Snapper, Kamber L. Hart, Roy H. Perlis   +4 more
doaj   +1 more source

Levels of genetic polymorphism: marker loci versus quantitative traits [PDF]

, 1998
Species are the units used to measure ecological diversity and alleles are the units of genetic diversity. Genetic variation within and among species has been documented most extensively using allozyme electrophoresis.
Butlin R. K., Butlin R. K., Meyer J., Muller H. J., Neems R. M., Nei M., Ward R. D., Watt W. B., Watt W. B., Wu C-I.   +9 more
core   +3 more sources

Multivariate Survival Mixed Models for Genetic Analysis of Longevity Traits [PDF]

, 2014
A class of multivariate mixed survival models for continuous and discrete time with a complex covariance structure is introduced in a context of quantitative genetic applications.
Labouriau, Rodrigo, Madsen, Per, Maia, Rafael Pimentel   +2 more
core   +2 more sources