Results 11 to 20 of about 7,425,705 (296)

Efficient Genome-wide Association in Biobanks Using Topic Modeling Identifies Multiple Novel Disease Loci

Molecular Medicine, 2017
Biobanks and national registries represent a powerful tool for genomic discovery, but rely on diagnostic codes that can be unreliable and fail to capture relationships between related diagnoses.
Thomas H. McCoy, Victor M. Castro, Leslie A. Snapper, Kamber L. Hart, Roy H. Perlis   +4 more
doaj   +1 more source

QUANTITATIVE GENETICS OF HETEROCHRONY [PDF]

Evolution, 1987
A model of quantitative-genetic variation in developmental processes is introduced and analyzed. The model is of a bifurcating sequence of events in which traits develop from the same tissue until a transition occurs, after which they develop partially independently.
openaire   +2 more sources

Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait

Nature Communications, 2019
Survival to extreme ages clusters within families. However, identifying genetic loci conferring longevity and low morbidity in such longevous families is challenging.
N. van den Berg, M. Rodríguez-Girondo, Ingrid K. van Dijk, Rick J. Mourits, K. Mandemakers, A. Janssens, M. Beekman, Ken R. Smith, P. Slagboom   +8 more
semanticscholar   +1 more source

Genetic parameters of meat quality traits in two pig breeds measured by rapid methods

Animal, 2010
To study genetic variation in meat quality traits measured by rapid methods, data were recorded between 2005 and 2008 on samples of M. longissimus dorsi (LD) in Landrace (n = 3838) and Duroc (n = 2250) pigs included in the Norwegian pig breeding scheme ...
E. Gjerlaug-Enger, L. Aass, J. Ødegård, O. Vangen   +3 more
doaj   +1 more source

Weighted single-step genomic best linear unbiased prediction integrating variants selected from sequencing data by association and bioinformatics analyses

Genetics Selection Evolution, 2020
Background Sequencing data enable the detection of causal loci or single nucleotide polymorphisms (SNPs) highly linked to causal loci to improve genomic prediction.
Aoxing Liu, Mogens Sandø Lund, Didier Boichard, Emre Karaman, Bernt Guldbrandtsen, Sebastien Fritz, Gert Pedersen Aamand, Ulrik Sander Nielsen, Goutam Sahana, Yachun Wang, Guosheng Su   +10 more
doaj   +1 more source

The Opportunities and Challenges of Integrating Population Histories Into Genetic Studies for Diverse Populations: A Motivating Example From Native Hawaiians

Frontiers in Genetics, 2021
There is a well-recognized need to include diverse populations in genetic studies, but several obstacles continue to be prohibitive, including (but are not limited to) the difficulty of recruiting individuals from diverse populations in large numbers and
Charleston W. K. Chiang, Charleston W. K. Chiang   +1 more
doaj   +1 more source

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Nature Genetics, 2021
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) analyses using ...
U. Võsa, A. Claringbould, H. Westra, M. Bonder, Patrick Deelen, B. Zeng, H. Kirsten, A. Saha, Roman Kreuzhuber, S. Yazar, H. Brugge, R. Oelen, Dylan H. de Vries, M. V. D. van der Wijst, S. Kasela, N. Pervjakova, I. Alves, M. Favé, M. Agbessi, M. Christiansen, R. Jansen, I. Seppälä, L. Tong, A. Teumer, K. Schramm, G. Hemani, J. Verlouw, H. Yaghootkar, Reyhan Sönmez Flitman, A. Brown, V. Kukushkina, A. Kalnapenkis, S. Rüeger, E. Porcu, J. Kronberg, J. Kettunen, Bernett Lee, Futao Zhang, Ting Qi, J. A. Hernandez, W. Arindrarto, F. Beutner, Julia Dmitrieva, Mahmoud Elansary, Benjamin P. Fairfax, M. Georges, B. Heijmans, A. Hewitt, M. Kähönen, Yungil Kim, J. Knight, P. Kovacs, K. Krohn, Shuang Li, M. Loeffler, U. Marigorta, Hailang Mei, Y. Momozawa, M. Müller-Nurasyid, M. Nauck, M. Nivard, B. Penninx, J. Pritchard, O. Raitakari, O. Rotzschke, E. Slagboom, C. Stehouwer, M. Stumvoll, P. Sullivan, P. '. ’t Hoen, J. Thiery, A. Tönjes, J. van Dongen, M. van Iterson, J. Veldink, U. Völker, R. Warmerdam, C. Wijmenga, M. Swertz, A. Andiappan, G. Montgomery, S. Ripatti, M. Perola, Z. Kutalik, E. Dermitzakis, S. Bergmann, T. Frayling, J. V. van Meurs, H. Prokisch, H. Ahsan, B. Pierce, T. Lehtimäki, D. Boomsma, B. Psaty, Sina A. Gharib, P. Awadalla, L. Milani, W. Ouwehand, K. Downes, O. Stegle, A. Battle, P. Visscher, Jian Yang, M. Scholz, J. Powell, G. Gibson, T. Esko, L. Franke   +107 more
semanticscholar   +1 more source

Genomic selection on breeding time in a wild bird population

Evolution Letters, 2019
Artificial selection experiments are a powerful tool in evolutionary biology. Selecting individuals based on multimarker genotypes (genomic selection) has several advantages over phenotype‐based selection but has, so far, seen very limited use outside ...
Phillip Gienapp, Mario P. L. Calus, Veronika N. Laine, Marcel E. Visser   +3 more
doaj   +1 more source

Potencial de híbridos simples de milho para extração de linhagens Potential of maize single hybrids to generate inbred lines

Ciência e Agrotecnologia, 2003
A utilização de híbridos simples comerciais de milho é uma das opções de populações para a extração de linhagens, porque são adaptados e provavelmente concentram alta freqüência de alelos favoráveis já fixados.
Odair Bison, Magno Antonio Patto Ramalho, Francislei Vitti Raposo   +2 more
doaj   +1 more source

Quantitative Genetics and Population Dynamics [PDF]

Evolution, 1996
This study examines the dynamics of a competition and a host-parasite model in which the interactions are determined by quantitative characters. Both models are extensions of one-dimensional difference equations that can exhibit complicated dynamics. Compared to these basic models, the phenotypic variability given by the quantitative characters reduces
openaire   +3 more sources