Results 151 to 160 of about 5,840,685 (292)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
The impact of SNP density on quantitative genetic analyses of body size traits in a wild population of Soay sheep. [PDF]
Ecol Evol, 2022 James C +3 more
europepmc +2 more sources
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Limitations of principal components in quantitative genetic association models for human studies. [PDF]
Elife, 2023 Yao Y, Ochoa A.
europepmc +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Reduced within-population quantitative genetic variation is associated with climate harshness in maritime pine. [PDF]
Heredity (Edinb), 2023 Archambeau J +5 more
europepmc +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Quantitative genetic analysis of floral traits shows current limits but potential evolution in the wild. [PDF]
Proc Biol Sci, 2023 Castellanos MC +5 more
europepmc +1 more source
, 2019 Trialeurodes vaporariorum Westwood (Hemiptera: Aleyrodidae), a haplo-diploid sap feeding insect species, is a vector of many plant viruses and a serious polyphagous pest of greenhouse-grown vegetables and ornamental plants worldwide.
Drobnjaković, Tanja +4 more
core