Results 181 to 190 of about 391,632 (299)

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Quantitative genetics of photosynthetic trait variation in maize. [PDF]

J Exp Bot
Ali W, Grzybowski M, Torres-Rodríguez JV, Li F, Shrestha N, Mathivanan RK, de Bernardeaux G, Hoang K, Mural RV, Roston RL, Schnable JC, Sahay S.   +11 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

When Metabolomics Meets Quantitative Genetics: An Integrative Strategy to Elucidate Plant Resistance Mechanisms. [PDF]

Plant Cell Environ
Lapous R, Amegan KE, Caromel B, Durel CE, Lavoir AV, Ferreira de Carvalho J, Larbat R.   +6 more
europepmc   +1 more source

The role of population and quantitative genetics and modern sequencing technologies to understand evolved herbicide resistance and weed fitness. [PDF]

Pest Manag Sci, 2021
Leon RG, Dunne JC, Gould F.
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Monte Carlo approximation of the logarithm of the determinant of large matrices with applications for linear mixed models in quantitative genetics. [PDF]

Genet Sel Evol
Bermann M, Alvarez-Munera A, Legarra A, Aguilar I, Misztal I, Lourenco D.   +5 more
europepmc   +1 more source

THE USE OF GENETICS PRINCIPLES IN RESEARCH EVALUATION: AN EXAMPLE WITH SOYBEANS

This paper explores the potential use of quantitative genetics principles in evaluating economic returns to plant breeding research. Basic factors affecting genetic progress are described along with possibilities for quantifying them in relation to ...
Norton, George W., Sundquist, W. Burt
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Variant calling in polyploids for population and quantitative genetics. [PDF]

Appl Plant Sci
Phillips AR.
europepmc   +1 more source