A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain
Zhang et al. uncover a novel central mechanism for persistent muscle pain, in which TRPA1 sensitization in MeV proprioceptive neurons enhances somatic secretion. This, in turn, disinhibits descending pain control from neighboring noradrenergic locus coeruleus neurons via local GABAergic circuits, thereby promoting inflammatory muscle pain.
Xiaoyu Zhang +15 more
wiley +1 more source
Developing a multidimensional scale of healing tourism experiences based on a mixed methods approach. [PDF]
Xie J, Li H, Chen Z, Wang H, Hua H.
europepmc +1 more source
Evaluating the Utilities of Foundation Models in Single‐Cell Data Analysis
This study delivers the first systematic, task‐level evaluation of single‐cell foundation models across eight core analytical tasks. By benchmarking 10 leading models with the scEval framework, it reveals where foundation models truly add value, where task‐specific methods still dominate, and provides concrete, reproducible guidelines to steer the next
Tianyu Liu +4 more
wiley +1 more source
Causal factors and configuration paths for chemical occupational accidents: grounded theory and fsQCA analysis of 154 cases in China. [PDF]
Wang Y, Zheng C, Wang L.
europepmc +1 more source
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source
Exploring a model of critical health literacy among Chinese physical education teachers: a grounded theory approach. [PDF]
Zhang Y, Yin Z, Xu R, Zhong Q, Liao Z.
europepmc +1 more source
Exploring the Journey of Patients Rehabilitated with Removable Complete Dentures: A Constructivist Grounded Theory Study. [PDF]
Chakaipa S +3 more
europepmc +1 more source
Qualitative research reporting in genetic counseling: A state-of-the-art assessment and recommendations for enhancing methodological congruence and quality. [PDF]
Wainstein T.
europepmc +1 more source

