Results 141 to 150 of about 5,789,434 (312)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Transcriptome-Guided Imaging Genetic Analysis via a Novel Sparse CCA Algorithm

, 2017
Imaging genetics is an emerging field that studies the influence of genetic variation on brain structure and function. The major task is to examine the association between genetic markers such as single nucleotide polymorphisms (SNPs) and quantitative ...
Kwangsik Nho, Nho, Kwangsik, Saykin, Andrew, Danai Chasioti, Liu, Kefei, Yao, Xiaohui, Chasioti, Danai, Kefei Liu, Shen, Li, Risacher, Shannon, Andrew Saykin, Li Shen, null null, Yan, Jingwen, Jingwen Yan, Xiaohui Yao, Shannon Risacher   +16 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Quantitative dynamic imaging of biological processes with solid state radiation detectors.

, 1999
The authors have developed a technique and a prototype for β-ray quantitative imaging of biological samples which have been radioactively labeled. The prototype is based on a solid state pixel detector, bump-bonded to a low threshold, single particle ...
C. DI CRISTO, MONTESI, MARIA CRISTINA, L. ABATE, RUSSO, PAOLO, METTIVIER, GIOVANNI, CONTI, MAURIZIO, BERTOLUCCI, ENNIO, DI COSMO, ANNA   +7 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

PD-0337 prostate IGRT using quantitative 3D ultrasound imaging: Intramodality US vs. MV imaging of implanted markers

, 2012
To allow for high precision radiotherapy, imaging prior to a radiation session is performed in Image Guided Radiotherapy (IGRT). Electronic portal imaging (EPI) can visualise bony anatomy and fiducial markers (FM).
Lutgens, L., van der Meer, S., Fontanarosa, D., Bloemen-van Gurp, E., Visser, P., Verhaegen, F., van Gils, F.   +6 more
core   +1 more source

Deep learning denoising reconstruction for improved image quality in fetal cardiac cine MRI

Frontiers in Cardiovascular Medicine
PurposeThis study aims to evaluate deep learning (DL) denoising reconstructions for image quality improvement of Doppler ultrasound (DUS)-gated fetal cardiac MRI in congenital heart disease (CHD).MethodsTwenty-five fetuses with CHD (mean gestational age:
Thomas M. Vollbrecht, Thomas M. Vollbrecht, Christopher Hart, Christopher Hart, Christopher Hart, Shuo Zhang, Christoph Katemann, Alois M. Sprinkart, Alois M. Sprinkart, Alexander Isaak, Alexander Isaak, Ulrike Attenberger, Claus C. Pieper, Daniel Kuetting, Daniel Kuetting, Annegret Geipel, Brigitte Strizek, Julian A. Luetkens, Julian A. Luetkens   +18 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Quantitative Magnetic Resonance Imaging: From Fingerprinting to Integrated Physics-Based Models

, 2019
Quantitative magnetic resonance imaging (qMRI) is concerned with estimating (in physical units) values of magnetic and tissue parameters, e.g., relaxation times $T_1$, $T_2$, or proton density $\rho$. Recently, in [Ma et al., Nature, 495 (2013), pp. 187--
Papafitsoros, Kostas, Dong, Guozhi, Hintermüller, Michael   +2 more
core   +1 more source