Results 121 to 130 of about 5,789,434 (312)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Rayleigh imaging in spectral mammography

, 2016
Spectral imaging is the acquisition of multiple images of an object at different energy spectra. In mammography, dual-energy imaging (spectral imaging with two energy levels) has been investigated for several applications, in particular material ...
Danielsson, Mats,, Fredenberg, Erik,, Berggren, Karl,   +2 more
core   +1 more source

Quantitative phase imaging with a multimode fiber [PDF]

Label-free quantitative phase imaging is vital for optical microscopy and metrology applications. A multimode fiber stands out as a desirable platform for imaging.
van Leeuwen, Tristan, Ivanina, Aleksandra, Marshall, Maxim, Abrashitova, Ksenia, Amitonova, Lyubov V.; id_orcid, Leeuwen, T. (Tristan) van, Maxim Marshall, Abrashitova, K. (Ksenia), Ivanina, A. (Aleksandra), Amitonova, L.V. (Lyubov), Aleksandra Ivanina, Ksenia Abrashitova, Tristan van Leeuwen, Lyubov V. Amitonova, Marshall, M. (Maxim)   +14 more
core   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Quantitative Magnetic Resonance Imaging of Cellular Density with TurboSPI

, 2012
Magnetic Resonance Imaging can now detect cells that are labeled with contrast agents such as superparamagnetic iron oxide (SPIO). Quantitative monitoring, which is desirable for evaluating cellular therapies, remains challenging.
Rioux, James
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Correlation of Patient Symptoms With Labral and Articular Cartilage Damage in Femoroacetabular Impingement

Orthopaedic Journal of Sports Medicine, 2018
Background: Femoroacetabular impingement (FAI) can lead to labral and articular cartilage injuries as well as early osteoarthritis of the hip. Currently, the association of patient symptoms with the progression of labral and articular cartilage injuries ...
Trevor Grace MD, Michael A. Samaan PhD, Richard B. Souza PT, PhD, Thomas M. Link MD, PhD, Sharmila Majumdar PhD, Alan L. Zhang MD   +5 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

HR-pQCT-based regional analysis reveals tibial spatial variability in cortical bone tissue quality in type 2 diabetic postmenopausal women with and without history of fragility fractures

Bone Reports, 2021
Ursula Heilmeier, Courtney Pasco, Meliss Yilmaz, Andrew J. Burghardt, Gabby B. Joseph, Thomas M. Link, Galateia J. Kazakia   +6 more
doaj   +1 more source