Results 61 to 70 of about 192,463 (317)

CGRP‐Loaded ROS‐Responsive Hydrogel Restores Neuro‐Angiogenic Signaling to Promote Bone Regeneration in Diabetes‐Associated Periodontitis

Advanced Science, EarlyView.
This study shows that diabetes damages sensory nerve fibers, especially CGRP‐positive ones, in the periodontium and disrupts autophagy in trigeminal ganglion neurons, affecting bone homeostasis by inhibiting type H vessel formation. To address this, CGRP@PVA/tsPBA hydrogels are developed to release CGRP in response to ROS, which binds to endothelial ...
Chaoning Zhan, Qingyi Dai, Jianhan Ren, Lijian Jin, Weiping Wang, Zhou Ye, James Kit Hon Tsoi, Yifan Lin   +7 more
wiley   +1 more source

The Menzerath–Altmann law: Experimenting with Tatar texts

Ученые записки Казанского университета: Серия Гуманитарные науки, 2021
The Menzerath–Altmann law on the relationship between the length of linguistic units and the length of their components is one of the important laws of quantitative linguistics.
A.M. Galieva
doaj   +1 more source

Ditransitive verbs and the ditransitive construction: a diachronic perspective [PDF]

, 2011
This paper argues for the adoption of a construction-based perspective to the investigation of diachronic shifts in valency, which is a hitherto largely neglected topic in the framework of valency grammar. On the basis of a comparison of the set of verbs
Colleman, Timothy
core   +2 more sources

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Text-Based Detection of the Risk of Depression

Frontiers in Psychology, 2019
This study examines the relationship between language use and psychological characteristics of the communicator. The aim of the study was to find models predicting the depressivity of the writer based on the computational linguistic markers of his/her ...
Jana M. Havigerová, Jiří Haviger, Dalibor Kučera, Petra Hoffmannová   +3 more
doaj   +1 more source

Discourse and identity in a corpus of lesbian erotica [PDF]

, 2011
This article uses corpus linguistic methodologies to explore representations of lesbian desires and identities in a corpus of lesbian erotica from the 1980s and 1990s.
Baker P., Baker P., Bolton R., Bright D., Bright S., Bright S., Bright S., Butler J., Butler J., Dworkin A., Frye M., Halberstam J., Helen Sauntson, Heywood J., Hunston S., Kennedy G., Lamos C., Liz Morrish, Mackinnon C., Manning E., McEnery T., Morrish E., Munt S., Rubin G., Scott M., Spender D., Stubbs M., Zita J.   +27 more
core   +1 more source

Directed Self‐Assembly of Magnetic Bioceramic Deep Inside Dentinal Tubules May Alleviate Dental Hypersensitivity

Advanced Science, EarlyView.
Magnetically guided bioceramic nanoparticles (“CalBots”) achieve deep dentinal tubule occlusion via directed self‐assembly under externally applied magnetic field. Various visualization techniques and a novel mouse behavioral assay indicate that CalBot‐induced plugs may reduce dentinal sensitivity, offering a promising strategy for future dentin ...
Shanmukh Peddi, Prajwal Hegde, Prannay Reddy, Anaxee Barman, Arnab Barik, Debayan Dasgupta, Ambarish Ghosh   +6 more
wiley   +1 more source

Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP‐Mediated Mechanosensitization of Intestinal Epithelial Cells

Advanced Science, EarlyView.
This study develops the hydrogel with antimicrobial, adhesive, degradable, injectable, and temperature‐sensitive contraction properties based on the transcriptomic and pathological characteristics of intestinal fistula patients. This hydrogel can seal rabbit intestinal fistula in situ, reduce the intestinal defect, and promote intestinal epithelial ...
Ze Li, Jiayang Li, Kang Chen, Guiwen Qu, Shuanghong Yang, Sicheng Li, Ye Liu, Yitian Teng, Rui Ma, Jinjian Huang, Peige Wang, Jianan Ren, Xiuwen Wu   +12 more
wiley   +1 more source

Tracing contact and migration in pre-Bantu Southern Africa through lexical borrowing

Evolutionary Human Sciences
Lexical borrowing may provide valuable clues about the sociohistorical context of language contact. Here we explore patterns of vocabulary transfer between languages from three families (Kx’a, Tuu, Khoe-Kwadi) comprising the linguistic unit commonly ...
Anne-Maria Fehn, Bonny E. Sands, Admire Phiri, Maitseo Bolaane, Gaseitsiwe Masunga, Ezequiel Fabiano, Jorge Rocha   +6 more
doaj   +1 more source

Lactate Dehydrogenase C4 Accelerates Triple‐Negative Breast Cancer Progression by Promoting Acetyl‐CoA Acyltransferase 2 Lactylation to Increase Free Fatty Acid Accumulation

Advanced Science, EarlyView.
Diagram of the reprogramming of FA metabolism mediated by LDHC4‐induced ACAA2 activity to promote TNBC progression. LDHC4 drives TNBC progression by enhancing ACAA2‐mediated fatty acid production. The resulting accumulation of FFAs stimulates autophagy and accelerates cell cycle progression, thereby promoting tumor growth.
Zhaolei Cui, Chaoqiang Zheng, Yingying Lin, Zhenzhou Xiao, Yanhong Li, Wei Peng, Shijie He, Anyang Li, Xiufeng Wu, Yan Chen, Yang Sun   +10 more
wiley   +1 more source