Results 111 to 120 of about 2,012,232 (260)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Introducing Angle B: A Novel Quantitative Approach for Sagittal Alignment Reduction in Atlanto-Axial Dislocation Surgery

Therapeutics and Clinical Risk Management
Shengyu Cui,1– 4 Xinyu Wang,1– 5 Kang Li,1– 4 Hailong Feng,6 Zhenlei Liu,1– 4 Fengzeng Jian,1– 4 Kai Wang1– 4 1Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Spine Center, China ...
Cui S, Wang X, Li K, Feng H, Liu Z, Jian F, Wang K   +6 more
doaj  

Optimisation and Validation of a Quantitative Method for the Analysis of Polymers of Nanoplastics in Human Faeces. [PDF]

Molecules
Torres E, Obon M, Moreno V, Moratalla-Navarro F, Esquena J, Llorca M, Farré M.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A New Quantitative Method for Assessing the Ultrastructure of Cardiomyocyte Mitochondria of the Right Atrial Appendage. [PDF]

Sovrem Tekhnologii Med
Kuzheleva EA, Garganeeva AA, Tukish OV, Syromyatnikova EE, Dorzhieva BB, Kondratiev MY, Andreev SL.   +6 more
europepmc   +1 more source

A quantitative method for determination of colistin E2 methanesulphonate in human plasma by ¹⁵N-labeled colistin E2. [PDF]

Sci Rep, 2023
Xu H, Li Y, Zhang J, Zhang J, Lu J, Zhang X, Yang L, Zhao W, Feng J.   +8 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Sequential Analysis of Murine Myelofibrosis Models Using a Novel Deep Learning-Based Fibrosis Quantitative Method. [PDF]

EJHaem
Kawamura T, Maekawa T, Kouzu K, Ogata H, Tachi N, Kato S, Osawa Y, Einama T, Sato K, Kobayashi S.   +9 more
europepmc   +1 more source

A quantitative method for the determination of rock fragmentation based on crack density and crack saturation. [PDF]

Sci Rep, 2023
Xiao Y, Deng H, Li J, Zhou M, Assefa E, Chen X.   +5 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source