Results 131 to 140 of about 2,012,232 (260)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Quantitative Method for Monitoring Tumor Evolution During and After Therapy. [PDF]

J Pers Med
Castorina P, Castiglione F, Ferini G, Forte S, Martorana E.   +4 more
europepmc   +1 more source

Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation. [PDF]

Cell Res, 2023
Chen L, Zhang LS, Ye C, Zhou H, Liu B, Gao B, Deng Z, Zhao C, He C, Dickinson BC.   +9 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

FluoTag-EMSA: a fast and accessible quantitative method to assess RNA-binding specificity using 3'-tagged hybrid duplexes. [PDF]

Front Mol Biosci
Rothé B, Constam DB.
europepmc   +1 more source

A stable and quantitative method for dimensionality reduction of aortic centerline. [PDF]

Front Cardiovasc Med, 2022
Peng T, Pu H, Qiu P, Yang H, Ju Z, Ma H, Zhang J, Chen K, Zhan Y, Sheng R, Wang Y, Zha B, Yang Y, Fang S, Lu X, Zhou J.   +15 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Clinical Quantitative Method Development of serum indoxyl sulfate (IS) assay using LC-MS/MS. [PDF]

Biochem Biophys Rep
Kobayashi S, Matsushita K, Kawasaki K, Seimiya M.   +3 more
europepmc   +1 more source

Corrigendum to "A quantitative method to analyse F-actin distribution in cells," [MethodsX 6 (2019), 2562-2569]. [PDF]

MethodsX, 2023
Zonderland J, Wieringa P, Moroni L.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source