Results 91 to 100 of about 6,427,693 (281)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Using Quantitative Methods as Support for Audit of the Distributed Informatics Systems [PDF]
This paper highlights some issues regarding how an indicators system must be developed and used in an audit process. Distributed systems are presented from de points of view of their main properties, architectures, applications, software quality ...
Marius POPA, Sergiu Marin CAPISIZU
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Making Every Dollar Count: How Expected Return Can Transform Philanthropy [PDF]
, 2008 Describes the benefits and methods of a quantitative process for evaluating potential program investments -- based on benefit, likelihood of success, the foundation's contribution, and cost -- to maximize return on ...
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Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
A detailed database of sub-annual Spanish demographic statistics: 2005–2021
Scientific DataThe big data revolution has made it possible to collect, transmit and exploit huge amounts of data. The potential this offer for data analysis, however, clashes with the limitations imposed by laws on protection of personal data. This paper details a new
Josep Lledó, Jose M. Pavía
doaj +1 more source
Does Expectation of Correlation Breakdown in Financial Market Fulfill Itself?
Discrete Dynamics in Nature and Society, 2015 This paper develops a model appeared in the literature whose focus was the way rational risk averse investors anticipate the correlation breakdowns of asset returns in periods of excess demand.
Paolo Falbo, Rosanna Grassi
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Investigating information systems with mixed-methods research [PDF]
, 2011 Mixed-methods research, which comprises both quantitative and qualitative components, is widely perceived as a means to resolve the inherent limitations of traditional single method designs and is thus expected to yield richer and more holistic findings.
Annansingh, F. +2 more
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Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source