Results 81 to 90 of about 6,427,693 (281)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Measuring Effectiveness of Quantitative Equity Portfolio Management Methods [PDF]
, 2008 In this paper, I use quantitative computer models to measure the effectiveness of Quantitative Equity Portfolio Management in predicting future stock returns using commonly accepted industry valuation factors.
Mesale, Andrew J.
core +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Can qualitative and quantitative methods serve complementary purposes for policy research? [PDF]
Qualitative and quantitative methods in social science research have long been separate spheres with little overlap. However, recent innovations have highlighted the complementarity of qualitative and quantitative approaches. The Accra Food and Nutrition
Maxwell, Daniel G.
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Analysis of the Stability and Chaotic Dynamics of an Ecological Model
ComplexityModelling has become an eminent tool in the study of ecological systems. Ecological modelling can help implement sustainable development, mathematical models, and system analysis that explain how ecological processes can promote the sustainable ...
Muhammad Aqib Abbasi +5 more
doaj +1 more source
A QUANTITATIVE ELECTROCARDIOGRAPHIC METHOD [PDF]
Heart, 1945 H E S, PEARSON, L M, GERLIS
openaire +3 more sources
Online Appendix to "Quantitative properties of sovereign default models: solution methods" [PDF]
This document describes how we evaluate the accuracy of the solution of the baseline sovereign default model using the test proposed by den Haan and Marcet (1994).
Horacio Sapriza +2 more
core
A comparative study of quantitative methods in ore microscopy: digital image analysis vs. point counter device [PDF]
, 2010 Quantitative mineralogical analyses of metallic concentrates from an ore-processing plant with reflected light microscopy have been carried out independently, on the same samples, by an expert mineralogist using a point counter device (PCD), and by ...
Castroviejo Bolibar, Ricardo +2 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source