Results 121 to 130 of about 6,427,693 (281)

Multi-objective optimization framework for sustainable olive oil supply chains: integrating environmental compliance with economic performance

Frontiers in Sustainability
IntroductionMediterranean olive oil production faces a critical sustainability challenge: managing olive mill wastewater (OMW), a highly polluting byproduct (0.8–1.2 m3/ton) threatening environmental compliance and supply chain viability.MethodsThis ...
Majdi Argoubi, Khaled Mili
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage. [PDF]

Medicina (Kaunas), 2023
Simion L, Ionescu S, Chitoran E, Rotaru V, Cirimbei C, Madge OL, Nicolescu AC, Tanase B, Dicu-Andreescu IG, Dinu DM, Luca DC, Stanculeanu DL, Gheorghe AS, Zob D, Marincas M.   +14 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

A Bilevel DEA Model for Efficiency Evaluation and Target Setting with Stochastic Conditions

Mathematics
The effective allocation of limited resources and the establishment of targeted goals play a pivotal role in enhancing the overall efficiency of large enterprises and organizations.
Andreas C. Georgiou, Konstantinos Kaparis, Eleni-Maria Vretta, Kyriakos Bitsis, George Paltayian   +4 more
doaj   +1 more source

Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers. [PDF]

Clin Proteomics, 2023
Kang N, Oh HJ, Hong JH, Moon HE, Kim Y, Lee HJ, Min H, Park H, Lee SH, Paek SH, Jin J.   +10 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Adaptive vehicle routing for humanitarian aid in conflict-affected regions: a practitioner-informed deep reinforcement learning approach

Frontiers in Future Transportation
Humanitarian aid delivery in conflict-affected regions faces significant challenges due to dynamic security risks, uncertain demand, and complex operational constraints. Traditional optimization methods struggle with computational intractability and lack
Khaled Mili, Majdi Argoubi
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Utilising quantitative methods to study the intersectionality of multiple social disadvantages in women with common mental disorders: a systematic review. [PDF]

Int J Equity Health, 2023
Alghamdi NA, Dunn K, Cairns D, Melville C.   +3 more
europepmc   +1 more source