Results 141 to 150 of about 3,161,536 (308)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Q-Squared in Policy: The Use of Qualitative and Quantitative Methods of Poverty Analysis in Decision-Making [PDF]
This introductory essay for the journal Symposium presents an overview of issues related to ‘Q-Squared in Policy: the use of qualitative and quantitative methods of poverty analysis in decision-making’.
Shaffer, Paul +3 more
core +1 more source
Using quantitative methods to understand leaf epidermal development. [PDF]
Quant Plant Biol, 2022 Kuan C, Yang SL, Ho CK.
europepmc +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Quantitative analysis of dependency structures Quantitative linguistics ;, v. 72./ edited by Jingyang Jiang, Haitao Liu. [PDF]
, 2018 In English.Includes bibliographical references and indexes.The series Quantitative Linguistics publishes books on all aspects of quantitative methods and models in linguistics, text analysis and related research fields.
Jiang Jingyang, Liu Haitao
core
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Utilising quantitative methods to study the intersectionality of multiple social disadvantages in women with common mental disorders: a systematic review. [PDF]
Int J Equity Health, 2023 Alghamdi NA +3 more
europepmc +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Qualitative and Quantitative Methods to Measure Antibacterial Activity Resulting from Bacterial Competition. [PDF]
Bio Protoc, 2023 Taillefer B +6 more
europepmc +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source