Results 161 to 170 of about 3,161,536 (308)

Quantitative Methods Used to Evaluate Impact of Combination HIV Prevention Intervention: A Methodological Systematic Review. [PDF]

AIDS Behav, 2023
Ravalihasy A, Ante-Testard PA, Kardas-Sloma L, Yazdanpanah Y, De Allegri M, Ridde V.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Smart home soundscape: constructing a perceptual model with qualitative and quantitative methods. [PDF]

Front Psychol
Li Z, Li M, Ba M, Xu W, Kang J.
europepmc   +1 more source

The Electroencephalographic Characterization of Hypsarrhythmia in Older Pediatric Population With Epilepsy Using Computer-Added Quantitative Methods. [PDF]

Cureus, 2023
Jha K, Kumar T, Zabihullah M, Kumar Y, Kumar R, Mishra A.   +5 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Quantitative Methods to Detect Suicide and Self-Harm Clusters: A Systematic Review. [PDF]

Int J Environ Res Public Health, 2022
Benson R, Rigby J, Brunsdon C, Cully G, Too LS, Arensman E.   +5 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Quantitative Methods in Agricultural Economics 1/ Quantitative Methods [PDF]

, 2023
ALS 3215/AEB 1204
core  

Antenatal ultrasound diagnosis of fetal micrognathia: validation and reproducibility of quantitative methods. [PDF]

Ultrasound Obstet Gynecol
Denk MC, Bertin M, Donadono V, Kangesu L, Yulia A, Ushakov F, Pandya PP, Napolitano R.   +7 more
europepmc   +1 more source

Advances in quantitative methods and modeling for complex generic drugs and opportunities to hybridize learnings between innovator and generic drug developers. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2023
Jayachandran P.
europepmc   +1 more source