Results 191 to 200 of about 6,427,693 (281)

One of the major challenges of masking the bitter taste in medications: an overview of quantitative methods for bitterness. [PDF]

Front Chem
Wang P, Li H, Wang Y, Dong F, Li H, Gui X, Ren Y, Gao X, Li X, Liu R.   +9 more
europepmc   +1 more source

Framework for Patient Experience Value Elements in Rare Disease: A Case Study Demonstrating the Applicability of Combined Qualitative and Quantitative Methods. [PDF]

Pharmacoecon Open, 2023
McQueen RB, Mendola ND, Jakab I, Bennett J, Nair KV, Németh B, Inotai A, Kaló Z.   +7 more
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Roadmap to Innovation of HTA Methods (IHTAM): insights from three case studies of quantitative methods. [PDF]

Int J Technol Assess Health Care
Jiu L, Wang J, Versteeg JW, Zhang Y, Liu L, Somolinos-Simón FJ, Tapia-Galisteo J, García-Sáez G, Hogervorst MA, Li X, Mantel-Teeuwisse AK, Goettsch WG.   +11 more
europepmc   +1 more source

Comparison of the chemical health risk assessment of exposure to metal fumes for the furnace operator of a foundry industry using quantitative and semi-quantitative methods. [PDF]

Heliyon, 2023
Zeverdegani SK, Ordudari Z, Karimi A, Esmaeili R, Khorvash MK.   +4 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Evaluation of Local Tumor Outcomes Following Microwave Ablation of Colorectal Liver Metastases Using CT Imaging: A Comparison of Visual versus Quantitative Methods. [PDF]

Radiol Imaging Cancer
Shur JD, Porta N, Kafaei L, Pendower L, McCall J, Khan N, Oyen W, Koh DM, Johnston E.   +8 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Magnetic Resonance Imaging (MRI)-Based Semi-Quantitative Methods for Rheumatoid Arthritis: From Scoring to Measurement. [PDF]

J Clin Med
Salaffi F, Carotti M, Di Carlo M, Ceccarelli L, Farah S, Poliseno AC, Di Matteo A, Bandinelli F, Giovagnoni A.   +8 more
europepmc   +1 more source