Results 91 to 100 of about 1,313,775 (264)

Quantitative Modeling of Arabidopsis Development

Plant Physiology, 2005
Abstract We present an empirical model of Arabidopsis (Arabidopsis thaliana), intended as a framework for quantitative understanding of plant development. The model simulates and realistically visualizes development of aerial parts of the plant from seedling to maturity.
Lars, Mündermann, Yvette, Erasmus, Brendan, Lane, Enrico, Coen, Przemyslaw, Prusinkiewicz   +4 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Expenditure and use on radiology imaging in urban and rural areas in a developing country

Cost Effectiveness and Resource Allocation
Background Changes in the population pyramid and in the disease burden of patients can be observed through the expenditure and frequency of use of medical imaging in health systems; however, this topic has undergone little study in the international ...
Oscar Espinosa, Gabriela Puentes, Valeria Bejarano, Javier Romero, Martha-Liliana Arias, Sandeep Hedgire, Dania Daye, Suyash Mohan, Richard Duszak   +8 more
doaj   +1 more source

Models of quantitative analysis of elasticity [PDF]

Ekonomija: teorija i praksa, 2019
This paper describes models of price elasticity using quantitative indicators. By observing the interdependence between the elasticity of the demand for some goods and the total consumption expenditure for this commodity, which can be equated with the ...
Ignjatijević Svetlana, Mihajlović Milan, Milojević Ivan   +2 more
doaj  

The role of quantitative models in geography

الأستاذ, 2018
The  aim  of   this  research  is  to highlight  the importance of  quantitative  trends  and statistical  methods  in  geographies   because  of  Based  on   the   data   of   the    General Company  for  the manufacture of grain for the quantity of ...
Assist.prof .Huda Abdel Kader Aziz, S.A Haifaa Abdel Kader Aziz   +1 more
doaj   +1 more source

Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis. [PDF]

Front Oncol, 2022
Chedere A, Mishra M, Kulkarni O, Sriraman S, Chandra N.   +4 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Explaining Redundancy in CDK-Mediated Control of the Cell Cycle: Unifying the Continuum and Quantitative Models. [PDF]

Cells, 2022
Fisher D, Krasinska L.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source