Results 101 to 110 of about 1,382,288 (265)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Quantitative models in urban planning [PDF]

مطالعات مدیریت بهبود و تحول, 1995
مدیریت جامعه باید با انتخاب یک سیستم پویا علاوه بر عوامل و پارامترهای معقول در بخش های کشاورزی، صنایع و خدمات و به منظور جلوگیری از آلودگی محیط زیست، تلاش برای دستیابی به منابع جدید، تجدید حیات موجود، توزیع بهینه جمعیت و ...، جامعه را به طرف کمال مطلوب ...
ali khaaki firouzabadi
doaj  

Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis. [PDF]

Front Oncol, 2022
Chedere A, Mishra M, Kulkarni O, Sriraman S, Chandra N.   +4 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Expenditure and use on radiology imaging in urban and rural areas in a developing country

Cost Effectiveness and Resource Allocation
Background Changes in the population pyramid and in the disease burden of patients can be observed through the expenditure and frequency of use of medical imaging in health systems; however, this topic has undergone little study in the international ...
Oscar Espinosa, Gabriela Puentes, Valeria Bejarano, Javier Romero, Martha-Liliana Arias, Sandeep Hedgire, Dania Daye, Suyash Mohan, Richard Duszak   +8 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Models of quantitative analysis of elasticity [PDF]

Ekonomija: teorija i praksa, 2019
This paper describes models of price elasticity using quantitative indicators. By observing the interdependence between the elasticity of the demand for some goods and the total consumption expenditure for this commodity, which can be equated with the ...
Ignjatijević Svetlana, Mihajlović Milan, Milojević Ivan   +2 more
doaj  

Explaining Redundancy in CDK-Mediated Control of the Cell Cycle: Unifying the Continuum and Quantitative Models. [PDF]

Cells, 2022
Fisher D, Krasinska L.
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A review of artificial intelligence in healthcare supply chains: untapped potential?

BMC Health Services Research
Background Supply chain management (SCM) is a central function of operational strategy and provides assurance of continuous delivery of services and products across different industries.
Oscar Espinosa, Sergio Basto, Angélica Ordóñez, Martha-Liliana Arias, Dino Sepúlveda, Mahmood F. Bhutta   +5 more
doaj   +1 more source