Results 171 to 180 of about 387,608 (286)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Imaging mass spectrometry approaches for the detection and localisation of drug compounds and small molecules in tissue [PDF]

A crucial and challenging aspect of the drug development process is the requirement to measure the distribution of a pharmaceutical compound and its metabolites in tissue.
Blatherwick, Eleanor Q.
core  

Primary assessment of medicines for expected migrastatic potential with holographic incoherent quantitative phase imaging. [PDF]

Biomed Opt Express, 2023
Šuráňová M, Ďuriš M, Štenglová Netíková I, Brábek J, Horák T, Jůzová V, Chmelík R, Veselý P.   +7 more
europepmc   +1 more source

Quantitative phase imaging for label‐free cytometry [PDF]

Cytometry Part A, 2017
Elena, Holden, Attila, Tárnok, Gabriel, Popescu   +2 more
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Towards a mobile quantitative phase imaging microscope with smartphone phase-detection sensors. [PDF]

Biomed Opt Express
Bao X, Hu ZD, Kreiss L, Lerner J, Horstmeyer R.   +4 more
europepmc   +1 more source

Multi-contrast digital histopathology of mouse organs using quantitative phase imaging and virtual staining. [PDF]

Biomed Opt Express, 2023
Min E, Aimakov N, Lee S, Ban S, Yang H, Ahn Y, You JS, Jung W.   +7 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Lensless Quantitative Phase Imaging with Bayer-Filtered Color Sensors Under Sequential RGB-LED Illumination. [PDF]

J Imaging
Wu J, Li Y, Luo Y, Pan L, Song P, Xu Q.
europepmc   +1 more source