Results 71 to 80 of about 659,328 (290)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A Comparison of Students’ Quantitative Reasoning Skills in STEM and Non-STEM Math Pathways

Numeracy, 2020
Quantitative Reasoning (QR) is essential for today’s students, yet most higher education institutions have not effectively addressed this issue. This study investigates students’ quantitative reasoning in STEM and Non-STEM math pathways using a non ...
Emily Elrod, Joo Young Park
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Exploring the episodic structure of algebra story problem solving [PDF]

, 1988
This paper analyzes the quantitative and situational structure of algebra story problems, uses these materials to propose an interpretive framework for written problem-solving protocols, and then presents an exploratory study of the episodic structure of
Hall, Rogers, Kibler, Dennis, Truxaw, Chris, Wenger, Etienne   +3 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

From counting in management to counting on management : making social science research matter [PDF]

, 2015
We have an unwavering faith in research substantiated by numbers. In the popular imagination, quantitative methods are still seen as the most robust and reliable means to inform decision making.
Nair, Anup Karath
core  

SNU_IDS at SemEval-2018 Task 12: Sentence Encoder with Contextualized Vectors for Argument Reasoning Comprehension

, 2018
We present a novel neural architecture for the Argument Reasoning Comprehension task of SemEval 2018. It is a simple neural network consisting of three parts, collectively judging whether the logic built on a set of given sentences (a claim, reason, and ...
Choi, Jihun, Kim, Taeuk, Lee, Sang-goo
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Unquantifiable: The Impacts of Len Vacher

Numeracy
This article celebrates H.L. (Len) Vacher, the founding editor of Numeracy. While many readers of this journal are no doubt familiar with Len’s contributions here and to quantitative literacy as a practice and habit of mind, fewer are intimately familiar
Victor Ricchezza, Nathan Grawe
doaj   +1 more source

Measuring Risk Literacy: The Berlin Numeracy Test

Judgment and Decision Making, 2012
We introduce the Berlin Numeracy Test, a new psychometrically sound instrument that quickly assesses statistical numeracy and risk literacy. We present 21 studies (n=5336) showing robust psychometric discriminability across 15 countries (e.g., Germany ...
Edward T. Cokely, Mirta Galesic, Eric Schulz, Saima Ghazal, Rocio Garcia-Retamero   +4 more
doaj   +1 more source