Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Integration with Writing Programs: A Strategy for Quantitative Reasoning Program Development
Numeracy, 2009 As an inherently interdisciplinary endeavor, quantitative reasoning (QR) risks falling through the cracks between the traditional “silos” of higher education. This article describes one strategy for developing a truly cross-campus QR initiative: leverage
Nathan D. Grawe, Carol A. Rutz
doaj +1 more source
An Uncommon Textbook: Review of Common Sense Mathematics by Ethan Bolker and Maura Mast
Numeracy, 2019 Ethan D. Bolker and Maura B. Mast. 2016. Common Sense Mathematics.(Washington DC.: Mathematics Association of America) ISBN-13: 978-1-93951-210-9. Common Sense Mathematics is an integrative quantitative reasoning (QR) textbook that is built around ...
Bernard L. Madison
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YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Review of Quantitative Reasoning: Tools for Today's Informed Citizen by A. Sevilla and K. Somers
Numeracy, 2008 Alicia Sevilla and Kay Somers, Quantitative Reasoning: Tools for Today’s Informed Citizen. (Emeryville CA: Key College Publishing, 2007). 626 pp. Softcover with Student CD. $79.95 (USA) ISBN 1-931914-90-1.
Aaron G. Montgomery
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Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Analysis of a COVID-19 Clinical Trial to Emphasize Experimental Design and Quantitative Reasoning in an Introductory Biology Course. [PDF]
J Microbiol Biol Educ, 2021 Grosser MR, Hale RE.
europepmc +1 more source
A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline
FEBS Open Bio, EarlyView.Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey +4 more
wiley +1 more source
A CURE for Meat: Comparing Bacterial Contaminants on Different Ground Beef Sources Emphasizes Process of Science and Quantitative Reasoning. [PDF]
J Microbiol Biol Educ, 2021 Boomer SM, Kumar S, Dutton BE.
europepmc +1 more source