Results 141 to 150 of about 54,399,869 (294)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Health Research Board: Health Research in Action [PDF]
This year’s Health Research in Action highlights some of the many notable impacts and outcomes of our work. It includes a snapshot in numbers of recent work completed, followed by 19 success stories about wide-ranging health and social care research ...
Health Research Board
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Electronic Cigarette Marketing: Current Research and Policy [PDF]
, 2016 This report outlines results from three separate but connected pieces of research. First, a review of the current e-cigarette market drawing on available data from market analysis, the trade press and other published sources. Secondly, a systematic rapid
Ford, Allison +3 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Qualitative Research Is Not a Modification of Quantitative Research [PDF]
Qualitative Health Research, 2005 openaire +2 more sources
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
National Mental Health Research Strategy [PDF]
This first national mental health research strategy for Ireland presents a unique opportunity to create a thriving mental health research system that can support mental health and wellbeing for all.
Health Research Board
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Health research in action 2018 [PDF]
, 2018 Actions and outcomes enabled by HRB-funded ...
Health Research Board
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source