Results 91 to 100 of about 643,998 (303)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Quantitative microbial risk assessment of haemolytic uremic syndrome associated with Argentinean kosher beef consumption in Israel

, 2023
Victoria Brusa, Sergio Dolev, Marcelo Signorini, Gerardo A. Leotta   +3 more
openalex   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Quantitative Risk Assessment [PDF]

Journal of Medical Ethics, 1989
openaire   +2 more sources

Extended Abstract to: Integrating Qualitative and Quantitative Risk Assessment Methods for Carbon Storage: A Case Study for the Quest Carbon Capture and Storage Facility

, 2022
C. F. Brown, Greg Lackey, Brandon Schwartz, Marcella Dean, Robert Dilmore, Hein Blanke, Simon O’Brien, Carrie Rowe   +7 more
openalex   +1 more source

SEMI-QUANTITATIVE METHODOLOGY FOR DISASTER RISK ASSESSMENT: THE CASE STUDY OF PIPUS VILLAGE, AMAZONAS DEPARTMENT, PERU [PDF]

, 2021
JHON E. CHAHUA JANAMPA, JHESSICA M. GUERRERO PINEDO   +1 more
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Quantitative Risk Assessment of Cruise Ship Turbocharger Failure: An Integrated Type-2 Fuzzy-Fmeca Approach Using Linear Opinion Pool Method

, 2023
Shoaib Ahmed, Tie Li, Xinyi Zhou
openalex   +1 more source

Case Study: Quantitative Risk Assessment ofStaphylococcus Aureus Enterotoxins in ArtisanFresh Cheese [PDF]

, 2021
Shukurullayev Lochin, Ailin Martínez Vasallo, René Tejedor Arias, Liesbeth Jacsens, Mieke Uyttendaele   +4 more
openalex   +1 more source