Results 71 to 80 of about 12,300,510 (297)

Quantitative Methods for Natech Risk Assessment

, 2017
Quantitative risk assessment is a powerful but complex and time-consuming task, which requires a significant amount of information and sophisticated models for the analysis of a very high number of scenarios even for rather simple plant layouts.
Cozzani, V., V. Cozzani, Salzano, E., E. Salzano   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Quantitative Assessment of Typhoon Disaster Risk at County Level

Journal of Marine Science and Engineering
Using the historical disaster records of 28 typhoons in Cangnan County since 2000, combining typhoon paths and hazard-bearing bodies data and based on the theoretical framework of climate change risk, the social and economic risks of typhoon disasters in
Guizhen Guo, Jie Yin, Lulu Liu, Shaohong Wu   +3 more
doaj   +1 more source

Quantitative Risk Assessment on a Hydrogen Refuelling Station

Chemical Engineering Transactions, 2018
The Directive 2014/94/UE (DAFI, Alternative Fuel Initiative Directive) on the deployment of alternative fuels (i.e. hydrogen) infrastructures has been recently transposed into national law in Italy.
Paola Russo, Alessandra De Marco, Michele Mazzaro, Luigi Capobianco   +3 more
doaj   +1 more source

Assessment of complex environmental health problems: framing the structures and structuring the frameworks. [PDF]

, 2010
Many environmental risks are multi-faceted and their health consequences can be far-ranging in both time and space. It can be a challenging task to develop informed policies for such risks.
Lebret, E., Briggs, D.J., Dep IRAS, Knol, A.B., Risk Assessment of Toxic and Immunomodulatory Agents   +4 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Neurotoxicity and risk assessment of brominated and alternative flame retardants [PDF]

, 2015
Brominatedflame retardants (BFRs) are widely used chemicals that prevent or slow the onset and spreading of fire. Unfortunately, many of these compounds pose serious threats for human health and the environment, indicating an urgent need for safe(r) and ...
Sub IRAS Tox CMT/NTX, Westerink, Remco H S, Hendriks, Hester S, IRAS RATIA1, Risk Assessment of Toxic and Immunomodulatory Agents   +4 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Q4MRATools: Quantitative tools to microbial risk assessment

EFSA Journal
In the context of the European Food Risk Assessment (EU‐FORA) fellowship programme, the project ‘Q4MRATools: Quantitative Tools to Microbial Risk Assessment’ focused on training in predictive microbiology, experimental design and the use of advanced ...
Olga María Bonilla Luque, Antonio Valero, Arícia Possas, Styliani Roufou, Jefferson deOliveira Mallia, Vasilis Valdramidis   +5 more
doaj   +1 more source

Quantitative microbial risk assessment of Legionella pneumophila in a drinking water distribution system: A case study

New Microbes and New Infections
Background: Legionella pneumophila poses a significant health risk in hospital water systems. This study assessed the risk associated with Legionella contamination in a hospital drinking water system in Sari, Iran, over one year.
Seyed Mohammad Ranjdoost, Mina Owrang
doaj   +1 more source