Results 71 to 80 of about 681,680 (256)

Assessing the Risk of Antimicrobial Resistant Enterococcal Infections in Humans Due to Bacitracin Usage in Poultry

Journal of Food Protection
Bacitracin is an antimicrobial used in the feed or water of poultry in the U.S. for the prevention, treatment, and control of clostridial diseases such as necrotic enteritis.
Randall S. Singer, Timothy J. Johnson
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Application of the Fuzzy Inference System in Risk Assessment of Sour Gas Pipelines [PDF]

بهداشت و ایمنی کار, 2023
Introduction: Pipelines are widely used to transport large volumes of oil and gas over long distances. Risk assessment can help identify risk factors and create an appropriate action plan and strategy to reduce or eliminate them.
Hamidreza Raeihagh, Azita Behbahaninia, Mina Macki Aleagha   +2 more
doaj  

Quantitative BSE risk assessment: relating exposures to risk [PDF]

Letters in Applied Microbiology, 1998
There is currently no epidemiological evidence to identify the route(s) of transmission of BSE from cattle to humans, although consumption of infected bovine offals, prior to their use being banned in human food in late 1989, is the most likely source.
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

RISK ASSESSMENT OF GAS PIPELINE CROSSING UNDER RAILWAY TRACKS AND DENSE RESIDENTIAL AREAS

Rekayasa Mesin
The crossing of Gas pipelines with railways is part of the energy transportation infrastructure that requires special attention, both to the operational safety of the pipeline and the railway line itself.
Angga Nurdiansyah, IGN Wiratmaja Puja, M Agus Kariem   +2 more
doaj   +1 more source

Risk Management and Analysis: Risk Assessment (Qualitative and Quantitative) [PDF]

SSRN Electronic Journal, 2010
We use to define risk as the possibility of suffering a loss. Starting this, risk management is defined as a business process whose purpose is to ensure that the organization is protected against risks and their effects. In order to prioritize, to develop a response plan and after that to monitor the identified risks we need to asses them.
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

RiskTree: Decision trees for asset and process risk assessment quantification in big data platforms

Security and Safety
Currently, big data platforms are widely applied across various industries. These platforms are characterized by large scale, diverse forms, high update frequency, and rapid data flow, making it challenging to directly apply existing risk quantification ...
Zhan Haomou, Yang Jiawei, Guo Zhenyang, Cao Jin, Zhang Dong, Zhao Xingwen, You Wei, Li Hui   +7 more
doaj   +1 more source