Results 51 to 60 of about 12,300,510 (297)
The use of modelling and probabilistic methods in cumulative risk assessment [PDF]
, 2008 This thesis was realized as part of the EU integrated project SAFE FOODS, the overall objective of which was to change the scope of decision-making on food safety from single risks to considering foods as sources of risks, benefits and costs associated ...
Dep IRAS +2 more
core +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Journal of Cloud Computing: Advances, Systems and Applications, 2023 Cloud computing adoption has been increasing rapidly amid COVID-19 as organisations accelerate the implementation of their digital strategies. Most models adopt traditional dynamic risk assessment, which does not adequately quantify or monetise risks to ...
Dawood Behbehani +3 more
doaj +1 more source
Mode of Action Frameworks in Toxicity Testing and Chemical Risk Assessment [PDF]
, 2009 Recently, legislative mandates worldwide are requiring systematic consideration of much larger numbers of chemicals. This necessitates more efficient and effective toxicity testing, as a basis to be more predictive in a risk assessment context.
Dep IRAS +2 more
core +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Risk assessment of N-nitrosodimethylamine formed endogenously after fish-with-vegetable meals [PDF]
, 2010 The consumption of fish and nitrate-rich vegetables may lead to the formation of the genotoxic carcinogen N-nitrosodimethylamine (NDMA) in the stomach. To assess human cancer risk associated with this formation, a dynamic in vitro gastrointestinal model ...
Slob, W. +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
20220110_RAG_Risk assessment pandemic law_NL
, 2022 RAG RA pandemic law 10-01 ...
Risk Assessment Group
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
, 2023 The purpose of the national risk assessment is to anticipate relatively sudden incidents potentially targeted at Finland that call for activities deviating from the norm from authorities or even requesting help from other countries.
core +1 more source