Results 141 to 150 of about 1,121,015 (394)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Quantitative sensory testing is feasible and is well-tolerated in patients with sickle cell disease following a vaso-occlusive episode

Journal of Pain Research, 2018
Nitya Bakshi,1 Ines Lukombo,1,2 Inna Belfer,3 Lakshmanan Krishnamurti1 1Division of Pediatric Hematology-Oncology, Department of Pediatrics, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2University of Pittsburgh, 3Department of ...
Bakshi N, Lukombo I, Belfer I, Krishnamurti L   +3 more
doaj  

Neural coding of a natural stimulus ensemble: Uncovering information at sub-millisecond resolution [PDF]

arXiv, 2006
Our knowledge of the sensory world is encoded by neurons in sequences of discrete, identical pulses termed action potentials or spikes. There is persistent controversy about the extent to which the precise timing of these spikes is relevant to the function of the brain.
arxiv  

Cheese: Food Perception and Food Choice [PDF]

, 2018
In light of the increasing interest in the economic and socio-political impact of the ‘traditional food’ trend, it is essential to understand the determinant factors that lead to traditional consumer choices.
Machado, Graça, Pinheiro, Cristina, Rodrigues, Lénia   +2 more
core   +1 more source

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Topology Optimization of Lattice Support Structure for Cantilever Beams Fabricated Via Laser Powder Bed Fusion

Advanced Engineering Materials, EarlyView., 2023
A numerical scheme is presented to design a lattice support for metallic components additively built via laser powder bed fusion. Results show that thermal‐induced distortion can be respectively reduced by 69%, 58%, and 50% in comparison to a uniform lattice, a fully solid support, and a truss‐based lattice support.
Jiazheng Hu, Marjan Molavi‐Zarandi, Damiano Pasini   +2 more
wiley   +1 more source

Tactile thresholds in healthy subjects

Zdravniški Vestnik, 2014
Background: The assessment of sensory thresholds provides a method of examining the function of peripheral nerve fibers and their central connections.
Metka Moharić, Gaj Vidmar
doaj  

Beyond numbers: integrating qualitative analysis into quantitative sensory testing for neuropathic pain

Frontiers in Pain Research
This article investigates the benefits of adopting qualitative and quantitative sensory testing (QQST) in sensory assessment, with a focus on understanding neuropathic pain.
Martine Bordeleau, Martine Bordeleau, Matthieu Vincenot, Matthieu Vincenot, Miroslav Bačkonja, Yenisel Cruz-Almeida, Yenisel Cruz-Almeida, Yenisel Cruz-Almeida, Julia Forstenpointner, Lynn Gauthier, Lynn Gauthier, Lynn Gauthier, Lynn Gauthier, Serge Marchand, Serge Marchand, Catherine Mercier, Catherine Mercier, Don Daniel Ocay, Don Daniel Ocay, Michel PrudHomme, Michel PrudHomme, Hélène Ruel, Jan Vollert, Guillaume Léonard, Guillaume Léonard   +24 more
doaj   +1 more source

Investigating the Feasibility of a Modified Quantitative Sensory Testing Approach to Profile Sensory Function and Predict Pain Outcomes Following Intrathecal Baclofen Implant Surgery in Cerebral Palsy.

Pain medicine (Malden, Mass.), 2019
OBJECTIVES Intrathecal baclofen (ITB) pumps used to manage spasticity in children with cerebral palsy (CP) also improve pain outcomes for some but not all patients.
C. Barney, A. Merbler, D. Simone, D. Walk, F. Symons   +4 more
semanticscholar   +1 more source

Pain perception and migraine [PDF]

, 2018
Background: It is well-known that both inter-and intra-individual differences exist in the perception of pain; this is especially true in migraine, an elusive pain disorder of the head.
Coppola, Gianluca, Parisi, Vincenzo, Pierelli, Francesco, Russo, Antonio, Silvestro, Marcello, Tedeschi, Gioacchino, Tessitore, Alessandro   +6 more
core   +1 more source