Results 31 to 40 of about 78,956 (246)

Tactile Detection in Fibromyalgia: A Systematic Review and a Meta-Analysis

Frontiers in Pain Research, 2021
Fibromyalgia is a chronic pain syndrome characterized by sensorimotor deficits and distortions of body representation, that could both be caused by alterations in sensory processing.
Tania Augière, Tania Augière, Audrey Desjardins, Audrey Desjardins, Emmanuelle Paquette Raynard, Clémentine Brun, Anne Marie Pinard, Anne Marie Pinard, Martin Simoneau, Martin Simoneau, Catherine Mercier, Catherine Mercier   +11 more
doaj   +1 more source

Carbamazepine for Chronic Muscle Pain: A Retrospective Assessment of Indications, Side Effects, and Treatment Response

Brain Sciences, 2023
Myopathies fall under the umbrella of rare diseases, however, muscle pain is a relevant, under-recognized symptom with limited treatment options. Carbamazepine is an oral sodium channel blocker approved for the treatment of seizures and neuropathic pain.
Tabea M. Dyong, Burkhard Gess, Christina Dumke, Roman Rolke, Maike F. Dohrn   +4 more
doaj   +1 more source

Quantitative sensory testing predicts pregabalin efficacy in painful chronic pancreatitis.

PLoS ONE, 2013
BackgroundA major problem in pain medicine is the lack of knowledge about which treatment suits a specific patient. We tested the ability of quantitative sensory testing to predict the analgesic effect of pregabalin and placebo in patients with chronic ...
Søren S Olesen, Carina Graversen, Stefan A W Bouwense, Harry van Goor, Oliver H G Wilder-Smith, Asbjørn M Drewes   +5 more
doaj   +1 more source

Pain mechanisms in complex regional pain syndrome: a systematic review and meta-analysis of quantitative sensory testing outcomes

Journal of Orthopaedic Surgery and Research, 2023
Background Complex regional pain syndrome (CRPS) is a chronic condition following inciting events such as fractures or surgeries with sensorimotor and autonomic manifestations and poor prognosis. This review aimed to provide conclusive evidence about the
Mohamed Gomaa Sobeeh, Karima Abdelaty Hassan, Anabela Gonçalves da Silva, Enas Fawzy Youssef, Nadia Abdelazim Fayaz, Maha Mostafa Mohammed   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Painful Intercourse Is Significantly Associated with Evoked Pain Perception and Cognitive Aspects of Pain in Women with Pelvic Pain

Sexual Medicine, 2015
Introduction: Evidence suggests that painful intercourse, pain-related psychosocial factors, and altered pain processing magnify the pain experience, but it is not clear how these factors are related to each other.
Meryl J. Alappattu, DPT, PhD, Steven Z. George, PT, PhD, Michael E. Robinson, PhD, Roger B. Fillingim, PhD, Nashat Moawad, MD, MS, Emily Weber LeBrun, MD, MS, Mark D. Bishop, PT, PhD   +6 more
doaj   +1 more source

Quantitative Sensory Testing Across Chronic Pain Conditions and Use in Special Populations

Frontiers in Pain Research, 2022
Chronic pain imposes a significant burden to the healthcare system and adversely affects patients' quality of life. Traditional subjective assessments, however, do not adequately capture the complex phenomenon of pain, which is influenced by a multitude ...
Kristen R. Weaver, Kristen R. Weaver, Mari A. Griffioen, Mari A. Griffioen, N. Jennifer Klinedinst, Elizabeth Galik, Ana C. Duarte, Luana Colloca, Luana Colloca, Barbara Resnick, Barbara Resnick, Susan G. Dorsey, Susan G. Dorsey, Cynthia L. Renn, Cynthia L. Renn   +14 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Movement-Evoked Pain and Temporal Summation in Individuals with Symptomatic Rotator Cuff Tears: A Cross-Sectional Study

Life
Musculoskeletal shoulder pain due to rotator cuff (RC) tears is a prevalent condition that significantly impacts function and quality of life. Understanding the underlying pain mechanisms, including movement-evoked pain (MEP) and pain facilitation ...
Anupama Prabhu B, Arun G. Maiya, Vivek Pandey, Kiran K. V. Acharya, Vennila Jaganathan, James M. Elliott, Mira Meeus   +6 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source