Results 281 to 290 of about 1,485,305 (342)

Modulating Oxide‐Based Quantum Materials by Ion Implantation

Advanced Functional Materials, EarlyView.
This review highlights how ion implantation, a well developed chip‐technology, enables targeted modulation of oxide‐based quantum materials. This includes tuning of metal‐insulator transitions, magnetism, and superconductivity through selective doping, defect creation, and induced lattice strain. Abstract Ion implantation has emerged as a powerful tool
Andreas Herklotz, Thomas Zac Ward, Shengqiang Zhou   +2 more
wiley   +1 more source

Wavelength‐Dependent Differential Amplification of Raman Scattering by Chiral Gold Nanorods for Multiplexed Encoding

Advanced Functional Materials, EarlyView.
The SERS spectra of reporter molecules adsorbed on chiral gold nanorods depends on the handedness of circularly polarized light (CPL‐SERS). The bisignate plasmonic CD spectra of chiral nanorods provides wavelength‐dependent CPL‐SERS. Selective discrimination of chiral nanorod handedness and different Raman reporters allow highly sensitive codification ...
Andrés Serrano‐Freijeiro, Carlos Renero‐Lecuna, Manuel Obelleiro‐Liz, Víctor F. Martín, Diptesh Dey, José M. Taboada, George C. Schatz, Isabel Pastoriza‐Santos, Jorge Pérez‐Juste, Luis M. Liz‐Marzán   +9 more
wiley   +1 more source

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

Edge‐Delocalized Electron Effect on Self‐Expediating Desolvation Kinetics for Low‐Temperature Li─S Batteries

Advanced Functional Materials, EarlyView.
The self‐transformed Schottky heterojunction on MXene is developed to facilitate the dissociation of Li (solvent)x+ to achieve fast Li+ desolvation to promote rapid sulfur conversion kinetics by decreasing the related barriers, contributing to high‐performance Li─S batteries under low‐temperatures.
Yongzheng Zhang, Xiang Li, Yanli Wang, Jianghao Zhu, Yinze Zuo, Xiaomin Cheng, Tao Rong, Jing Zhang, Yang Hu, Hongzhen Lin, Jian Wang, Liang Zhan, Licheng Ling   +12 more
wiley   +1 more source

Quantitative Structure-Activity Relationships and Carminative Activity [PDF]

Journal of Pharmaceutical Sciences, 1978
Carminative activities of 34 alcohols, esters, ethers, phenols, and carbonyl compounds were determined using the guinea pig isolated ileum preparation and are expressed as the ability to produce a 50% inhibition (ID50) of a standard response to carbachol. Aqueous solubilities were measured at 37 degrees using either UV absorption or GLC.
K C James, David K. Luscombe, Brian K. Evans   +2 more
openaire   +2 more sources

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Ecotoxicological Quantitative Structure–Activity Relationships for Pharmaceuticals

Bulletin of Environmental Contamination and Toxicology, 2007
This paper examined active pharmaceutical ingredients (APIs) acute ecotoxicological modes of action (MOA). It was concluded that the vast majority of APIs acute MOA was non-specific narcosis as; 85% out of 59 APIs had an excess toxicity ratio
Sanderson, H., Thomsen, M.
openaire   +4 more sources

Quantitative structure-activity relationships

1979
Designing of biologically active molecules on a rational basis is of utmost importance to medicinal chemists. Until about the late 1950’s most of the structure-activity correlations were emperical and qualitative. Although attempts have been made to apply quantitative methods to biological activity since last century, a major effort in this field has ...
Anil K. Saxena, S. Ram
openaire   +3 more sources

A Quantitative Structure-Activity Relationship Model

Chemical Product and Process Modeling, 2008
Structure-activity relationships were studied for a series of 46 2.6-dimethyl-3.5-dicabomethoxy-4-phenyl-1.4-dihydropyridine derivatives by means of multiple linear regression (MLR) and artificial neural network (ANN) techniques. The values of log (1/EC50), which represents the 50% effective concentration for blocking the Ca2+ channel of the studied ...
Mohamed Nohair, M. Abdellah Bahlaoui, Rokaya Mouhibi, Marouan Bnoumarzouk, Mohamed Zahouily, Mohamed Lazar   +5 more
openaire   +2 more sources

Quantitative Structure Activity Relationships in Drug Metabolism

Current Topics in Medicinal Chemistry, 2006
This review of 61 references delineates contemporary computation quantitative structure activity relationship (QSAR) approaches that have been used to elucidate the molecular features that influence the binding and metabolism of a compound by the major phase 1 and phase 2 metabolising enzymes; Cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT),
Kamaldeep K. Chohan, Stuart W. Paine, Nigel J. Waters   +2 more
openaire   +3 more sources

Quantitative Structure–Activity Relationships of Antimicrobial Compounds [PDF]

, 2012
A thorough antimicrobial reviewof an increasing number of reports reveals a broad spectrum of research activity in the development practices that are used to treat a variety of diseases. The quantitative relationship between chemical structure and biological activity has received considerable attention in recent years because it allows one to predict ...
N. B. Okulik, Eduardo Alberto Castro, Fabiana P. Maguna   +2 more
openaire   +1 more source