Results 291 to 300 of about 1,485,305 (342)

Quantitative Structure Activity Relationships: An overview

2018
Presentation at an SOT specialty section webinar on QSAR Nov ...
Prachi Pradeep, 0000-0002-9219-4249
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Organotins and Quantitative‐Structure Activity/Property Relationships

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Xueqing Song, George Eng, Alejandra Zapata   +2 more
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Quantitative structure—activity relationships (QSAR)

Chemometrics and Intelligent Laboratory Systems, 1989
Abstract Dunn III, W.J., 1989. Quantitative structure-activity relationships (QSAR). Chemometrics and Intelligent Laboratory Systems , 6: 181–190. Drug design has been influenced considerably since the first quantitative structure-activity relationship (QSAR) study was published by Hansch and his coworkers in 1962.
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Quantitative Structure-Activity Relationships [PDF]

, 1974
The ultimate goal of the medicinal chemist is to discover a molecule which will produce a desired biological effect without producing undesirable biological effects. This extremely difficult assignment can, at the present state of art in drug design, only be approached.
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ChemInform Abstract: TOXICITY AND QUANTITATIVE STRUCTURE‐ACTIVITY RELATIONSHIPS OF COLCHICINES

Chemischer Informationsdienst, 1981
A method for extracting LD50 values from antitumor test data is described. A quantitative structure--activity relationship (QSAR) for 7- and 10-substituted colchicines is presented. This correlation equation closely parallels that which had been derived earlier for potency. This result indicates that attempts to modify 7- and 10-substituted colchicines
Zohar Neiman, Frank R. Quinn, John A. Beisler   +2 more
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Quantitative structure-activity relationships of antihypertensive agents [PDF]

, 1999
Quantitative structure-activity relationships of various classes of antihypertensive agents, e.g., sympatholytic agents, diuretics, direct or peripheral vasodilators, potassium channel activators, angiotensin-converting enzyme inhibitors, renin inhibitors and miscellaneous agents (platelet aggregation inhibitors) are reviewed.
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Quantitative Structure-Activity Relationships of Renin Inhibitors

Mini-Reviews in Medicinal Chemistry, 2003
A review is presented on quantitative structure-activity relationships (QSARs) of renin inhibitors which have potential as antihypertensive and cardiovascular agents. They inhibit the renin, an enzyme that is involved in the rate-limiting first step of the renin angiotensin system (RAS).
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Quantitative Structure-activity Relationships Of (+)-anatoxin-a Derivatives

Natural Product Letters, 1994
Abstract The QSAR of a series of 21 nicotinic agonists, anatoxin-a (AnTX) and derivatives, was investigated using multivariate statistical techniques. Physicochemical properties were calculated for the compounds using computational chemistry. In order to model the structures it was necessary to choose a common conformation.
Gallagher, TC, Manallack, DT, Ellis, DD, Thompson, PE, Livingstone, DJ   +4 more
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Descriptor Selection Improvements for Quantitative Structure-Activity Relationships

International Journal of Neural Systems, 2019
Molecular descriptor selection is an essential procedure to improve a predictive quantitative structure–activity relationship (QSAR) model. However, within the QSAR model, there are a number of redundant, noisy and irrelevant descriptors. In this study, we propose a novel descriptor selection framework using self-paced learning (SPL) via sparse ...
Qingyong Wang, Yong Liang, Liang-Yong Xia, Zehong Cao   +3 more
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Quantitative structure-activity relationships of antianginal drugs

2001
Quantitative structure-activity relationships (QSARs) of various classes of antianginal drugs, e.g. nitrates, beta-adrenergic blocking agents (beta-blockers), and calcium channel blockers (calcium antagonists), have been reviewed. This review gives an overall picture of the mode of action of each class of drugs and points out the specific ...
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